Iron is an essential micronutrient that is problematic for biological systems since it is toxic as
it generates free radicals by interconverting between ferrous (Fe 2+) and ferric (Fe 3+) forms …

As the population ages, the incidence of neurodegenerative diseases is increasing. Due to
intensive research, important steps in the elucidation of pathogenetic cascades have been …

The present study reports a highly efficient and green synthetic route for the synthesis of
steroidal pyridines. The synthetic methodology involves a microwave-assisted one-pot …

Interactome maps are valuable resources to elucidate protein function and disease
mechanisms. Here, we report on an interactome map that focuses on neurodegenerative …

Ayurveda is the medicinal science, dealing with utilization of naturally available plant
products for treatment. A wide variety of neuroprotective herbs have been reported in …

The serine/threonine protein kinases CDK2 and GSK-3β are key oncotargets in breast
cancer cell lines, therefore, in the present study three series of oxindole-benzofuran hybrids …

Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD)
and amyotrophic lateral sclerosis (ALS), are typically characterized by progressive neuronal …

Protein dyshomeostasis is the common mechanism of neurodegenerative diseases such as
Alzheimer's disease (AD). Aging is the key risk factor, as the capacity of the proteostasis …

Neuronal inflammation is a systematically organized physiological step often triggered to
counteract an invading pathogen or to rid the body of damaged and/or dead cellular debris …

Emerging evidence indicates that Ca2+ is a vital factor in modulating the pathogenesis of
Alzheimer's disease (AD). In healthy neurons, Ca2+ concentration is balanced to maintain a …