The bioinorganic chemistry of mammalian metallothioneins

A Krezel, W Maret - Chemical reviews, 2021 - ACS Publications
The functions, purposes, and roles of metallothioneins have been the subject of
speculations since the discovery of the protein over 60 years ago. This article guides …

Silver nanoparticles: Toxicity in model organisms as an overview of its hazard for human health and the environment

GR Tortella, O Rubilar, N Durán, MC Diez… - Journal of hazardous …, 2020 - Elsevier
Silver nanoparticles (AgNPs) have attracted remarkable attention due to their powerful
antimicrobial action as well as their particular physicochemical properties. This has led to …

A guide to human zinc absorption: general overview and recent advances of in vitro intestinal models

M Maares, H Haase - Nutrients, 2020 - mdpi.com
Zinc absorption in the small intestine is one of the main mechanisms regulating the systemic
homeostasis of this essential trace element. This review summarizes the key aspects of …

Antioxidant and anti-inflammatory effects of zinc. Zinc-dependent NF-κB signaling

M Jarosz, M Olbert, G Wyszogrodzka, K Młyniec… - …, 2017 - Springer
Zinc is a nutritionally fundamental trace element, essential to the structure and function of
numerous macromolecules, including enzymes regulating cellular processes and cellular …

The toxicology of mercury: Current research and emerging trends

G Bjørklund, M Dadar, J Mutter, J Aaseth - Environmental research, 2017 - Elsevier
Mercury (Hg) is a persistent bio-accumulative toxic metal with unique physicochemical
properties of public health concern since their natural and anthropogenic diffusions still …

[HTML][HTML] An overview of carcinogenic heavy metal: molecular toxicity mechanism and prevention

HS Kim, YJ Kim, YR Seo - Journal of cancer prevention, 2015 - ncbi.nlm.nih.gov
Almost all heavy metals are serious toxicants as carcinogens. However, due to their
chemical and physiological properties, heavy metals are useful in industrial areas including …

[HTML][HTML] Zinc and oxidative stress: current mechanisms

DN Marreiro, KJC Cruz, JBS Morais, JB Beserra… - Antioxidants, 2017 - mdpi.com
Oxidative stress is a metabolic dysfunction that favors the oxidation of biomolecules,
contributing to the oxidative damage of cells and tissues. This consequently contributes to …

Metallothionein 1: A new spotlight on inflammatory diseases

H Dai, L Wang, L Li, Z Huang, L Ye - Frontiers in immunology, 2021 - frontiersin.org
MT1 has been demonstrated to be an essential stress protein in maintaining physiological
balance and regulating immune homeostasis. While the immunological involvement of MT1 …

Arsenic binding to proteins

S Shen, XF Li, WR Cullen, M Weinfeld, XC Le - Chemical reviews, 2013 - ACS Publications
Arsenic is a trace element found in the earth, s crust at an average concentration of∼ 5 μg/g
(ppm). Although its relative abundance in the earth, s crust is about 54th, arsenic can …

[HTML][HTML] The role of metallothionein in oxidative stress

B Ruttkay-Nedecky, L Nejdl, J Gumulec, O Zitka… - International journal of …, 2013 - mdpi.com
Free radicals are chemical particles containing one or more unpaired electrons, which may
be part of the molecule. They cause the molecule to become highly reactive. The free …