The immune system plays a crucial role in cancer development either by fostering tumor
growth or destroying tumor cells, which has open new avenues for cancer immunotherapy. It …

In contrast to the predominant population of B-2 B cells produced in the bone marrow, B-1 B
cells are a minor population of B lymphocytes that are found in multiple tissues, including the …

Genome-scale studies have revealed extensive, cell type-specific colocalization of
transcription factors, but the mechanisms underlying this phenomenon remain poorly …

Nuclear organization has been implicated in regulating gene activity. Recently, large
developmentally regulated regions of the genome dynamically associated with the nuclear …

It has traditionally been believed that the production of immunoglobulin (Ig) molecules is
restricted to B lineage cells. However, immunoglobulin genes and proteins have been …

Background A recent comparative genomic analysis tentatively identified roughly 40
orthologous groups of C2H2 Zinc-finger proteins that are well conserved in" bilaterians"(ie …

NKL homeobox genes are basic regulators of cell and tissue differentiation, many acting as
oncogenes in T-cell leukemia. Recently, we described an hematopoietic NKL-code …

The role of hedgehog (Hh) signaling in B lymphopoiesis has remained unclear. We
observed that the proliferation of pro-B cells in stromal cocultures was impaired by …

The hepatocyte NF (HNF) family of transcription factors regulates the complex gene
networks involved in lipid, carbohydrate, and protein metabolism. In humans, HNF1A …

The hallmark of B-cell development is the ordered recombination of immunoglobulin (Ig)
genes. Recently, considerable progress has been achieved in assembling gene regulatory …