Following its transcription, RNA can be modified by> 170 chemically distinct types of
modifications—the epitranscriptome. In recent years, there have been substantial efforts to …

Mitochondria, originally of bacterial origin, are highly dynamic organelles that have evolved
a symbiotic relationship within eukaryotic cells. Mitochondria undergo dynamic, stage …

Summary The N 6-methyladenosine (m 6 A) RNA modification is used widely to alter the fate
of mRNAs. Here we demonstrate that the C. elegans writer METT-10 (the ortholog of mouse …

Lead, a common metallic contaminant, is widespread in the living environment, and has
deleterious effects on the reproductive systems of humans and animals. Although numerous …

Amino acids are now recognised as having multiple cellular functions in addition to their
traditional role as constituents of proteins. This is well-illustrated in the early mammalian …

Postovulatory oocyte aging has a major influence on the development potential of embryos.
Many antioxidants can delay oocyte aging by regulating the expression of SIRT1. However …

In this review we discuss the beneficial effects of amino acid transport and metabolism on
pre-and peri-implantation embryo development, and we consider how disturbances in these …

Aspergillus flavus and its toxic aflatoxins secondary metabolites contaminate food and
grains, posing a severe threat to human health and leading to liver cancer. Here, we …

Medically assisted reproduction, now considered a routine, successful treatment for infertility
worldwide, has produced at least 8 million live births. However, a growing body of evidence …

Maturation of oocytes and early embryo development are regulated precisely by numerous
factors at transcriptional and posttranslational levels through precise mechanisms. N6 …