Gadolinium‐based contrast agents for magnetic resonance cancer imaging

Z Zhou, ZR Lu - Wiley Interdisciplinary Reviews: Nanomedicine …, 2013 - Wiley Online Library
Magnetic resonance imaging (MRI) is a clinical imaging modality effective for anatomical
and functional imaging of diseased soft tissues, including solid tumors. MRI contrast agents …

Modeling tracer kinetics in dynamic Gd‐DTPA MR imaging

PS Tofts - Journal of magnetic resonance imaging, 1997 - Wiley Online Library
Three major models (from Tofts, Larsson, and Brix) for collecting and analyzing dynamic MRI
gadolinium‐diethylenetriamine penta‐acetic acid (Gd‐DTPA) data are examined. All models …

Macromolecules, dendrimers, and nanomaterials in magnetic resonance imaging: the interplay between size, function, and pharmacokinetics

AJL Villaraza, A Bumb, MW Brechbiel - Chemical reviews, 2010 - ACS Publications
Magnetism in medicine has had a long and interesting history. In the 10th century AD,
Egyptian physician and philosopher Avicenna prescribed a grain of magnetite dissolved in …

A new macromolecule as a contrast agent for MR angiography: preparation, properties, and animal studies.

AA Bogdanov Jr, R Weissleder, HW Frank… - Radiology, 1993 - pubs.rsna.org
The authors developed and evaluated a polymer as a contrast agent for magnetic
resonance (MR) angiography. The agent consists of a monomethoxy ether of poly (ethylene …

Modeling regional myocardial flows from residue functions of an intravascular indicator

K Kroll, N Wilke, M Jerosch-Herold… - American Journal …, 1996 - journals.physiology.org
The purpose of the present study was to determine the accuracy and the sources of error in
estimating regional myocardial blood flow and vascular volume from experimental residue …

Measurement of vascular volume fraction and blood‐tissue permeability constants with a pharmacokinetic model: studies in rat muscle tumors with dynamic Gd‐DTPA …

MY Su, JC Jao, O Nalcioglu - Magnetic resonance in medicine, 1994 - Wiley Online Library
We propose a compartmental model to explain the signal enhancement curves following the
bolus injection of Gd‐DTPA. The model incorporates vascular volume fraction contribution …

Contrast-enhanced MR imaging of the lung: assessments of ventilation and perfusion.

Y Berthezene, V Vexler, O Clement, A Mühler… - Radiology, 1992 - pubs.rsna.org
The use of aerosolized gadopentetate dimeglumine to define regional lung ventilation and
of intravenously administered polylysine-(gadopentetate dimeglumine) 40 to assess …

Regional myocardial blood volume and flow: first‐pass MR imaging with polylysine‐Gd‐DTPA

N Wilke, K Kroll, H Merkle, Y Wang… - Journal of Magnetic …, 1995 - Wiley Online Library
The authors investigated the utility of an intra‐vascular magnetic resonance (MR) contrast
agent, poly‐L‐lysine‐gadolinium diethylenetriaminepentaacetic acid (DTPA), for …

Contrast-enhanced MR angiography: theory and optimization

MR Prince - Magnetic Resonance Imaging Clinics of North America, 1998 - Elsevier
It is now possible to perform contrast arteriography safely and rapidly by taking advantage of
gadolinium contrast agents and 3D MR imaging. Although development of this approach to …

Biodistribution and metabolism of targeted and nontargeted protein-chelate-gadolinium complexes: evidence for gadolinium dissociation in vitro and in vivo

FN Franano, WB Edwards, MJ Welch… - Magnetic resonance …, 1995 - Elsevier
The intracellular metabolism of receptor-targeted 153Gd-DTPA-glycoproteins was studied in
vitro and in vivo. These agents bound to cell surface receptors, underwent receptor …