From a clinical, morphological and molecular perspective, prostate cancer is a
heterogeneous disease. Primary prostate cancers are often multifocal, having …

The minimal structural unit of a solid tumor is a single cell or a cellular compartment such as
the nucleus. A closer look inside the cells reveals that there are functional compartments or …

Genome-wide DNA sequencing was used to decrypt the phylogeny of multiple samples from
distinct areas of cancer and morphologically normal tissue taken from the prostates of three …

Prostate cancer is characterized by a high degree of heterogeneity, which poses a major
challenge to precision therapy and drug development. In this review, we discuss how …

Effective clinical management of prostate cancer (PCA) has been challenged by significant
intratumoural heterogeneity on the genomic and pathological levels and limited …

There are remarkable disparities among patients of different races with prostate cancer;
however, the mechanism underlying this difference remains unclear. Here, we present a …

Highlights•Patients who receive antiandrogen treatments are more likely to develop
CRPC.•A genomic landscape study has identified aberrant epigenetic events in CRPC and …

Background Most primary prostate cancers are multifocal with individual tumors harboring
different aggressiveness; however, the genomic heterogeneity among these tumors is poorly …

Extracellular vesicles (EVs) have attracted interest due to their ability to provide diagnostic
information from liquid biopsies. Cells constantly release vesicles divers in size, content and …

Prostate cancer (PCa) is one of the most commonly diagnosed malignancies and among the
leading causes of cancer-related death worldwide. It is a highly heterogeneous disease …