Clinical biology of the pituitary adenoma
S Melmed, UB Kaiser, MB Lopes, J Bertherat… - Endocrine …, 2022 - academic.oup.com
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …
The role of cellular senescence in ageing and endocrine disease
S Khosla, JN Farr, T Tchkonia… - Nature Reviews …, 2020 - nature.com
With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …
Pituitary-tumor endocrinopathies
S Melmed - New England Journal of Medicine, 2020 - Mass Medical Soc
Pituitary-Tumor Endocrinopathies Pituitary adenomas account for about 15% of intracranial
tumors. Clinical manifestations of disease reflect the oversecretion of the involved hormone …
tumors. Clinical manifestations of disease reflect the oversecretion of the involved hormone …
Diagnosis and treatment of pituitary adenomas: a review
ME Molitch - Jama, 2017 - jamanetwork.com
Importance Pituitary adenomas may hypersecrete hormones or cause mass effects.
Therefore, early diagnosis and treatment are important. Observations Prevalence of pituitary …
Therefore, early diagnosis and treatment are important. Observations Prevalence of pituitary …
Acromegaly: an endocrine society clinical practice guideline
L Katznelson, ER Laws Jr, S Melmed… - The Journal of …, 2014 - academic.oup.com
Objective: The aim was to formulate clinical practice guidelines for acromegaly. Participants:
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …
Mutations in the deubiquitinase gene USP8 cause Cushing's disease
Cushing's disease is caused by corticotroph adenomas of the pituitary. To explore the
molecular mechanisms of endocrine autonomy in these tumors, we performed exome …
molecular mechanisms of endocrine autonomy in these tumors, we performed exome …
Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)
RV Thakker, PJ Newey, GV Walls… - The Journal of …, 2012 - academic.oup.com
Objective: The aim was to provide guidelines for evaluation, treatment, and genetic testing
for multiple endocrine neoplasia type 1 (MEN1). Participants: The group, which comprised …
for multiple endocrine neoplasia type 1 (MEN1). Participants: The group, which comprised …
Multiple endocrine neoplasia type 1 (MEN1): an update and the significance of early genetic and clinical diagnosis
CDC Kamilaris, CA Stratakis - Frontiers in endocrinology, 2019 - frontiersin.org
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor syndrome inherited in
an autosomal dominant manner and characterized by a predisposition to a multitude of …
an autosomal dominant manner and characterized by a predisposition to a multitude of …
Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody
S Iwama, A De Remigis, MK Callahan… - Science translational …, 2014 - science.org
Hypophysitis is a chronic inflammation of the pituitary gland of unknown (primary forms) or
recognizable (secondary forms) etiology, such as the use of ipilimumab in cancer …
recognizable (secondary forms) etiology, such as the use of ipilimumab in cancer …
Hypothalamus‐pituitary‐thyroid axis
TM Ortiga‐Carvalho, MI Chiamolera… - Comprehensive …, 2011 - Wiley Online Library
The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …