Clinical biology of the pituitary adenoma

S Melmed, UB Kaiser, MB Lopes, J Bertherat… - Endocrine …, 2022 - academic.oup.com
All endocrine glands are susceptible to neoplastic growth, yet the health consequences of
these neoplasms differ between endocrine tissues. Pituitary neoplasms are highly prevalent …

The role of cellular senescence in ageing and endocrine disease

S Khosla, JN Farr, T Tchkonia… - Nature Reviews …, 2020 - nature.com
With the ageing of the global population, interest is growing in the 'geroscience hypothesis',
which posits that manipulation of fundamental ageing mechanisms will delay (in parallel) the …

Pituitary-tumor endocrinopathies

S Melmed - New England Journal of Medicine, 2020 - Mass Medical Soc
Pituitary-Tumor Endocrinopathies Pituitary adenomas account for about 15% of intracranial
tumors. Clinical manifestations of disease reflect the oversecretion of the involved hormone …

Diagnosis and treatment of pituitary adenomas: a review

ME Molitch - Jama, 2017 - jamanetwork.com
Importance Pituitary adenomas may hypersecrete hormones or cause mass effects.
Therefore, early diagnosis and treatment are important. Observations Prevalence of pituitary …

Acromegaly: an endocrine society clinical practice guideline

L Katznelson, ER Laws Jr, S Melmed… - The Journal of …, 2014 - academic.oup.com
Objective: The aim was to formulate clinical practice guidelines for acromegaly. Participants:
The Task Force included a chair selected by the Endocrine Society Clinical Guidelines …

Mutations in the deubiquitinase gene USP8 cause Cushing's disease

M Reincke, S Sbiera, A Hayakawa… - Nature …, 2015 - nature.com
Cushing's disease is caused by corticotroph adenomas of the pituitary. To explore the
molecular mechanisms of endocrine autonomy in these tumors, we performed exome …

Clinical practice guidelines for multiple endocrine neoplasia type 1 (MEN1)

RV Thakker, PJ Newey, GV Walls… - The Journal of …, 2012 - academic.oup.com
Objective: The aim was to provide guidelines for evaluation, treatment, and genetic testing
for multiple endocrine neoplasia type 1 (MEN1). Participants: The group, which comprised …

Multiple endocrine neoplasia type 1 (MEN1): an update and the significance of early genetic and clinical diagnosis

CDC Kamilaris, CA Stratakis - Frontiers in endocrinology, 2019 - frontiersin.org
Multiple endocrine neoplasia type 1 (MEN1) is a rare hereditary tumor syndrome inherited in
an autosomal dominant manner and characterized by a predisposition to a multitude of …

Pituitary expression of CTLA-4 mediates hypophysitis secondary to administration of CTLA-4 blocking antibody

S Iwama, A De Remigis, MK Callahan… - Science translational …, 2014 - science.org
Hypophysitis is a chronic inflammation of the pituitary gland of unknown (primary forms) or
recognizable (secondary forms) etiology, such as the use of ipilimumab in cancer …

Hypothalamus‐pituitary‐thyroid axis

TM Ortiga‐Carvalho, MI Chiamolera… - Comprehensive …, 2011 - Wiley Online Library
The hypothalamus‐pituitary‐thyroid (HPT) axis determines the set point of thyroid hormone
(TH) production. Hypothalamic thyrotropin‐releasing hormone (TRH) stimulates the …