The pulmonary endothelium is a highly regulated organ that performs a wide range of
functions under physiological and pathological conditions. Since endothelial dysfunction …

Plasminogen activator inhibitor 1 (PAI-1), a SERPIN inhibitor, is primarily known for its
regulation of fibrinolysis. However, it is now known that this inhibitor functions and …

D-dimer is a fibrin degradation product encompassing multiple cross-linked D domains
and/or E domains present in the original fibrinogen molecule, whose generation is only …

The intestinal lumen harbors a diverse consortium of microorganisms that participate in
reciprocal crosstalk with intestinal immune cells and with epithelial and endothelial cells …

Background Fibrinolysisis is essential for vascular blood flow maintenance and is triggered
by endothelial and platelet release of tissue plasminogen activator (t-PA). In certain critical …

The crosstalk between viral infections, amyloid formation and neurodegeneration has been
discussed with varying intensity since the last century. Several viral proteins are known to be …

Viruses have been present during all evolutionary steps on earth and have had a major
effect on human history. Viral infections are still among the leading causes of death. Another …

COVID-19, the infectious disease caused by severe acute respiratory syndrome coronavirus-
2 (SARS-CoV-2), is frequently associated with pulmonary thrombotic events, especially in …

Fibrinolysis is the system primarily responsible for removal of fibrin deposits and blood clots
in the vasculature. The terminal enzyme in the pathway, plasmin, is formed from its …

Although there is increasing evidence that oxidative stress and inflammation induced by
COVID-19 may contribute to increased risk and severity of thromboses, the underlying …