The emergence of the novel SARS coronavirus 2 (SARS-CoV-2), the causative agent of
coronavirus disease 2019 (COVID-19), has resulted in an unprecedented pandemic that has …

Heart failure is a leading cause of mortality and hospitalization worldwide. Cardiac fibrosis,
resulting from the excessive deposition of collagen fibers, is a common feature across the …

Background Excessive myocardial fibrosis is the pathological basis of heart failure following
myocardial infarction (MI). Although calycosin improves cardiac function, its effect on cardiac …

Cardiac fibrosis is characteristic of the end stage in nearly all forms of heart disease.
Accumulation of extracellular matrix in the myocardium leads to increased risk of arrhythmia …

BACKGROUND: Cardiac inflammation in heart failure is characterized by the presence of
damage-associated molecular patterns, myeloid cells, and T cells. Cardiac damage …

Quercetin has multiple protective effects against cardiometabolic diseases, but the biological
mechanisms underlying the benefits in diabetic cardiomyopathy (DCM) are unclear. A …

Cell communication is needed for organ function and stress responses, especially in the
heart. Cardiac fibroblasts, cardiomyocytes, immune cells and endothelial cells comprise the …

Abstract Quizalofop-P-ethyl (QpE), a highly efficient selective herbicide, has good control
effect on annual and perennial weeds. However, its excessive use will pose a threat to the …

Aims Despite the broad pharmacological arsenal to treat hypertension, chronic patients may
develop irreversible cardiac remodeling and fibrosis. Angiotensin II, the main peptide …

Background: NLRP3 inflammasome contributes a lot to sterile inflammatory response and
pyroptosis in ischemia/reperfusion (I/R) injury. Cardiac fibroblasts (CFs) are regarded as …