Background and Objectives Pathogenic variants in STXBP1 are among the major genetic
causes of neurodevelopmental disorders. Despite the increasing number of individuals …

Objective Infantile spasm syndrome (ISS) is an epileptic encephalopathy without established
treatment after the failure to standard of care based on steroids and vigabatrin. Converging …

Infantile spasms (IS) syndrome is a catastrophic, epileptic encephalopathy of infancy that is
often refractory to current antiepileptic therapies. The ketogenic diet (KD) has emerged as an …

Abstract Vigabatrin (VGB), adrenocorticotropic hormone (ACTH), and prednisone are first‐
line treatments for infantile spasms (IS). A recent study reported benefits from the use of …

Infantile spasms (IS) is an epileptic encephalopathy with unique clinical and electrographic
features, which affects children in the middle of the first year of life. The pathophysiology of …

Objective: Children with infantile spasms may develop Lennox-Gastaut syndrome. The
diagnostic criteria for Lennox-Gastaut syndrome are vague, and many experts use varying …

This study explores the etiology and lead time to treatment for infantile spasm (IS) patients
and their effect on treatment responsiveness, in a limited resource setting. Patients with IS …

Objective This study was undertaken to evaluate our treatment algorithm for infantile
epileptic spasms syndrome (IESS) used between 2000 and 2018. We initiated vigabatrin …

Epilepsy is one of the main symptoms affecting the lives of individuals with tuberous
sclerosis complex (TSC), causing a high rate of morbidity. Individuals with TSC can present …

Infantile spasm (IS) is a distinct epilepsy syndrome characterized by epileptic spasms (the
clinical seizure type) and hypsarrhythmia (the electrographic abnormality). IS is frequently …