After intense scientific exploration and more than a decade of failed trials, Alzheimer's
disease (AD) remains a fatal global epidemic. A traditional research and drug development …

Endometriosis is a common chronic pain condition with no known cure and limited treatment
options. Digital technologies, ranging from smartphone apps to wearable sensors, have …

Tumor growth curves are classically modeled by means of ordinary differential equations. In
analyzing the Gompertz model several studies have reported a striking correlation between …

Whether CD8+ T lymphocytes control human immunodeficiency virus infection by cytopathic
or non-cytopathic mechanisms is not fully understood. Multiple studies highlighted non …

Personalised federated learning (FL) aims at collaboratively learning a machine learning
model tailored for each client. Albeit promising advances have been made in this direction …

The decay kinetics of HIV-1-infected cells are critical to understand virus persistence. We
evaluated the frequency of simian immunodeficiency virus (SIV)-infected cells for 4 years of …

The saemix package for R provides maximum likelihood estimates of parameters in
nonlinear mixed effect models, using a modern and efficient estimation algorithm, the …

Defining tumor stage at diagnosis is a pivotal point for clinical decisions about patient
treatment strategies. In this respect, early detection of occult metastasis invisible to current …

Early prediction of human clearance is often challenging, in particular for the growing
number of low-clearance compounds. Long-term in vitro models have been developed …

Despite several clinical trials implemented, no antiviral drug could demonstrate efficacy
against Ebola virus. In non-human primates, early initiation of polymerase inhibitors …