Background The rates of antibiotic resistance in Gram-negative bacteria are increasing. One
method to minimize resistance emergence may be optimization of antibiotic dosing …

Objective: Dose optimization of novel β-lactam antibiotics (NBLA) has become necessary
given the increased prevalence of multidrug-resistant infections in intensive care units …

Background Early and appropriate antibiotic dosing is associated with improved clinical
outcomes in critically ill patients, yet target attainment remains a challenge. Traditional …

Variants of SARS-CoV-2 have emerged that are more transmissible than the original virus or
that exhibit some properties of immune escape, or both. The beta (B. 1.351) variant has …

Objectives Beta-lactam antibiotics are often subject to therapeutic drug monitoring, but
breakpoints of target attainment are mostly based on expert opinions. Studies that show a …

Various studies have reported insufficient beta-lactam concentrations in critically ill patients.
The extent to which therapeutic drug monitoring (TDM) in clinical practice can reduce …

Necrotizing soft tissue infections (NSTIs) are rare life-threatening bacterial infections
characterized by an extensive necrosis of skin and subcutaneous tissues. Initial urgent …

Augmented renal clearance is commonly observed in septic patients and may result in
insufficient β-lactam serum concentrations. The aims of this study were to evaluate potential …

Abstract Background Several population pharmacokinetic (PopPK) models for meropenem
dosing in ICU patients are available. It is not known to what extent these models can predict …

Despite their limitations, the pharmacokinetics (PK) and pharmacodynamics (PD) indices
form the basis for our current understanding regarding antibiotic development, selection …