Botanical polysaccharides exhibit a number of beneficial therapeutic properties, and it is
thought that the mechanisms involved in these effects are due to the modulation of innate …

The fetal inflammatory response syndrome (FIRS) is a condition characterized by systemic
inflammation and an elevation of fetal plasma interleukin-6. This syndrome has been …

Rationale: Sepsis refers to the clinical syndrome of severe systemic inflammation
precipitated by infection. Despite appropriate antimicrobial therapy, sepsis-related morbidity …

To identify new components that regulate the inflammatory cascade during sepsis, we
characterized the functions of myeloid-related protein-8 (Mrp8, S100A8) and myeloid-related …

Exposure to a variety of toxins and/or infectious agents leads to disease, degeneration and
death, often characterised by circumstances in which cells or tissues do not merely die and …

The triggering receptor expressed on myeloid cells (TREM)-1 is a recently discovered
receptor expressed on the surface of neutrophils and a subset of monocytes. Engagement of …

Macrophage migration inhibitory (MIF) factor is an immunoregulatory cytokine whose effect
on arresting random immune cell movement was recognized several decades ago. Despite …

Macrophage migration inhibitory factor (MIF) is a pivotal regulator of the immune response.
Neutralization or genetic deletion of MIF does not completely abrogate activation responses …

The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in
physiology by its ability to directly regulate the immunosuppressive actions of …

Cholestasis is a common complication in patients with extrahepatic bacterial infection and
sepsis. This article gives a comprehensive overview of the molecular and cellular …