Biomolecular condensates, membrane-less entities arising from liquid–liquid phase
separation, hold dichotomous roles in health and disease. Alongside their physiological …

Abstract Parkinson's disease (PD), the second most common progressive
neurodegenerative disease, develops and progresses for 10–15 years before the clinical …

For the last two decades, pathogenic concepts in Parkinson disease (PD) have revolved
around the toxicity and spread of α-synuclein. Thus, α-synuclein would follow caudo-rostral …

Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …

Background Recent studies point toward a significant impact of cardiovascular processes
and inflammation on Parkinson's disease (PD) progression. Objective The aim of this study …

Nature has developed a plethora of protein machinery to operate and maintain nearly every
task of cellular life. These processes are tightly regulated via post‐expression modifications …

Recently, there has been growing interest in exosomal biomarkers for their active targeting
and specificity for delivering their cargos (proteins, lipids, nucleic acids) from the parent cell …

Two recent, high‐profile manuscripts reported negative results with two parallel approaches
of passive immunization targeting α‐synuclein in a population of patients with early …

In Parkinson's disease (PD), and other α-synucleinopathies, α-synuclein (α-Syn) aggregates
form a myriad of conformational and truncational variants. Most antibodies used to detect …

Since the description of some peculiar symptoms by James Parkinson in 1817, attempts
have been made to define its cause or at least to enlighten the pathology of “Parkinson's …