The use of simulated biological fluids (SBFs) is a promising in vitro technique to better
understand the release mechanisms and possible in vivo behaviour of materials, including …

Oral inhalation results in pulmonary drug targeting and thereby reduces systemic side
effects, making it the preferred means of drug delivery for the treatment of respiratory …

Highlights•PBPK modeling bridges drug properties and PK behaviours in drug discovery
and development.•The PBPK is often used in oral formulation development, to address …

Micro−/nanocarriers due to their significant advantages are widely investigated in pulmonary
drug delivery. However, different size carriers have varied drug release rate, concealing the …

Bioavailability assessment in the development phase of a drug product is vital to reveal the
disadvantageous properties of the substance and the possible technological interventions …

Pulmonary delivery has gained increased interests over the past few decades. For
conditions within the respiratory tract, targeted drug delivery directly to the site of action can …

For oral drugs, the formulator and discovery chemist have a tool available to them that can
be used to navigate the risks associated with the selection and development of immediate …

Introduction Drugs delivered via the lungs are predominantly used to treat various
respiratory disorders, including asthma, chronic obstructive pulmonary diseases, respiratory …

Purpose Amorphous solid dispersions (ASD) for nasal delivery offer the opportunity to
increase drug release performance, while using polymers with mucoadhesive properties …

Pulmonary drug administration provides a platform for the effective local treatment of various
respiratory diseases. Application of nano-sized active ingredients results in higher …