Musculoskeletal pain conditions are age-related, leading contributors to chronic pain and
pain-related disability, which are expected to rise with the rapid global population aging …

Acetaminophen (APAP)-induced liver injury (AILI) is a common liver disease in clinical
practice. Only one clinically approved drug, N-acetylcysteine (NAC), for the treatment of AILI …

TRPM2 channels admit Ca2+ and Na+ across the plasma membrane and release Ca2+ and
Zn2+ from lysosomes. Channel activation is initiated by reactive oxygen species (ROS) …

Background & Aims Acute liver failure (ALF) is a condition with high mortality and morbidity,
characterized by glutathione depletion, oxidative stress, and mitochondrial dysfunction …

Background Acetaminophen (APAP) overdose is a major cause of the morbidity of acute
liver failure. The current clinically approved treatment for APAP poisoning, N-acetylcysteine …

Abstract Background Cirsii Japonici Herba Carbonisata (Dajitan in Chinese) has been used
to treat liver disorders in Asian countries. Pectolinarigenin (PEC), an abundant constituent in …

Nuclear factor erythroid 2-related factor 2 (NRF2) is a transcription factor responsible for
mounting an anti-oxidation gene expression program to counter oxidative stress. Under …

Aims Acute liver failure (ALF) is a life-threatening disease characterized by abrupt and
extensive hepatic necrosis and apoptosis, resulting in high mortality. The approved drug, N …

Paracetamol (PCM) and diclofenac (DCF) are extensively used analgesic and antipyretic
drugs over the counter. Their increasing levels in water bodies cause serious environmental …

Drug-induced liver injury (DILI) is one of the most frequent sources of liver failure and the
leading cause of liver transplant. Common non-prescription medications such as non …