Revisiting the cholinergic hypothesis in the development of Alzheimer's disease

LA Craig, NS Hong, RJ McDonald - Neuroscience & Biobehavioral …, 2011 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia affecting the elderly
population today; however, there is currently no accurate description of the etiology of this …

Repairing the human brain after stroke: I. Mechanisms of spontaneous recovery

SC Cramer - Annals of neurology, 2008 - Wiley Online Library
Stroke remains a leading cause of adult disability. Some degree of spontaneous behavioral
recovery is usually seen in the weeks after stroke onset. Variability in recovery is substantial …

Increased brain injury and worsened neurological outcome in interleukin-4 knockout mice after transient focal cerebral ischemia

X Xiong, GE Barreto, L Xu, YB Ouyang, X Xie… - Stroke, 2011 - Am Heart Assoc
Background and Purpose—Stroke causes brain injury with activation of an inflammatory
response that can contribute to injury. We tested the hypothesis that the anti-inflammatory …

Experimental models of brain ischemia: a review of techniques, magnetic resonance imaging, and investigational cell-based therapies

A Canazza, L Minati, C Boffano, E Parati… - Frontiers in …, 2014 - frontiersin.org
Stroke continues to be a significant cause of death and disability worldwide. Although major
advances have been made in the past decades in prevention, treatment, and rehabilitation …

Myricetin ameliorates brain injury and neurological deficits via Nrf2 activation after experimental stroke in middle-aged rats

S Wu, Y Yue, A Peng, L Zhang, J Xiang, X Cao… - Food & Function, 2016 - pubs.rsc.org
The aim of our study was to investigate the protective effects and underlying mechanisms of
myricetin, a bioactive food compound, on brain injury and neurological deficits after ischemic …

Gait impairment in a rat model of focal cerebral ischemia

S Parkkinen, FJ Ortega, K Kuptsova… - Stroke research and …, 2013 - Wiley Online Library
The availability of proper tests for gait evaluation following cerebral ischemia in rats has
been limited. The automated, quantitative CatWalk system, which was initially designed to …

Propofol pretreatment attenuates aquaporin-4 over-expression and alleviates cerebral edema after transient focal brain ischemia reperfusion in rats

YY Zheng, YP Lan, HF Tang, SM Zhu - Anesthesia & Analgesia, 2008 - journals.lww.com
BACKGROUND: Cerebral edema is a major threat for stroke victims. Most studies have
focused on the neuroprotective activities of propofol, addressing infarct volume rather than …

Combined contrast-enhanced ultrasound and rt-PA treatment is safe and improves impaired microcirculation after reperfusion of middle cerebral artery occlusion

M Nedelmann, N Ritschel, S Doenges… - Journal of Cerebral …, 2010 - journals.sagepub.com
In monitoring of recanalization and in sonothrombolysis, contrast-enhanced ultrasound
(CEUS) is applied in extended time protocols. As extended use may increase the probability …

Propofol attenuates cerebral ischemia/reperfusion injury partially using heme oxygenase-1

C Liang, J Cang, H Wang, Z Xue - Journal of Neurosurgical …, 2013 - journals.lww.com
Background: To investigate the protective effects of propofol in brain ischemia/reperfusion
injury and the role of heme oxygenase-1 (HO-1) in this process. Methods: Sprague-Dawley …

[HTML][HTML] Secretomes of apoptotic mononuclear cells ameliorate neurological damage in rats with focal ischemia

P Altmann, M Mildner, T Haider, D Traxler, L Beer… - …, 2014 - ncbi.nlm.nih.gov
The pursuit of targeting multiple pathways in the ischemic cascade of cerebral stroke is a
promising treatment option. We examined the regenerative potential of conditioned medium …