Glutamate-mediated excitotoxicity is an important mechanism leading to post ischemic
stroke damage. After acute stroke, the sudden reduction in cerebral blood flow is most …

A phenotype of indefinite growth arrest acquired in response to sublethal damage, cellular
senescence affects normal aging and age-related disease. Mitogen-activated protein …

Flavonoids are an important class of natural polyphenolic compounds reported to exert
beneficial effects in cardiovascular and metabolic diseases, cancer, autoimmune and …

Abstract Parkinson's disease (PD), the most common movement disorder, comprises several
pathophysiologic mechanisms including misfolded alpha‐synuclein aggregation …

The progression of neurodegenerative disorders is mainly characterized by immense
neuron loss and death of glial cells. The mechanisms which are active and regulate …

Parkinson's disease (PD) is the most common neurodegenerative movement disorder, with
current treatment being mainly symptomatic and often accompanied by serious side effects …

The mitogen-activated protein kinase (MAPK) p38 is an essential family of kinases,
regulating responses to environmental stress and inflammation. There is an ever-increasing …

Parkinson disease (PD)-affected brains show consistent endoplasmic reticulum (ER) stress
and mitophagic dysfunctions. The mechanisms underlying these perturbations and how they …

Human exposure to endocrine disruptors (EDs) has attracted considerable attention in
recent years. Different studies showed that ED exposure may exacerbate the deterioration of …

Aglycone-and glycoside-derived forms of flavonoids exist broadly in plants and foods such
as fruits, vegetables, and peanuts. However, most studies focus on the bioavailability of …