Noncanonical functions of the autophagy machinery in pathways including LC3-associated
phagocytosis and LC3-associated endocytosis have garnered increasing interest in both …

Cancer growth represents a dysregulated imbalance between cell gain and cell loss, where
the rate of proliferating mutant tumour cells exceeds the rate of those that die. Apoptosis, the …

Autophagy is an intracellular self-degradative mechanism which responds to cellular
conditions like stress or starvation and plays a key role in regulating cell metabolism, energy …

Macroautophagy is a conserved catabolic process observed in all eukaryotic cells, during
which selected cellular components are transported to and broken down within lysosomes …

Autophagy is a conserved catabolic process that degrades cytoplasmic constituents and
organelles in the lysosome. Starvation-induced protein degradation is a salient feature of …

Abstract LC3-associated phagocytosis (LAP) is a process wherein elements of autophagy
conjugate LC3 to phagosomal membranes. We characterize the molecular requirements for …

Abstract p53 is a crucial tumour suppressor that responds to diverse stress signals by
orchestrating specific cellular responses, including transient cell cycle arrest, cellular …

Significance: Autophagy is a highly conserved eukaryotic cellular recycling process.
Through the degradation of cytoplasmic organelles, proteins, and macromolecules, and the …

Cancer involves cells' abnormal growth and ability to invade or metastasize to different body
parts. Cancerous cells can divide uncontrollably and spread to other areas through the …

Induction of cell death and inhibition of cell survival are the main principles of cancer
therapy. Resistance to chemotherapeutic agents is a major problem in oncology, which …