Pleural mesothelioma (PMe): The evolving molecular knowledge of a rare and aggressive cancer

M Rigon, L Mutti, M Campanella - Molecular Oncology, 2024 - Wiley Online Library
Mesothelioma is a type of late‐onset cancer that develops in cells covering the outer surface
of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining …

Immune checkpoint inhibitors in malignant pleural mesothelioma: a systematic review and meta-analysis

M Gemelli, DL Cortinovis, A Baggi, P di Mauro, S Calza… - Cancers, 2022 - mdpi.com
Simple Summary Many clinical trials have investigated the role of Immune Checkpoint
Inhibitors (ICIs) in pleural mesothelioma (PM), with contrasting results. We performed a …

The STING agonist, DMXAA, reduces tumor vessels and enhances mesothelioma tumor antigen presentation yet blunts cytotoxic T cell function in a murine model

PT Graham, AK Nowak, SMJ Cornwall, I Larma… - Frontiers in …, 2022 - frontiersin.org
We assessed the murine Stimulator of Interferon Genes (STING) agonist, DMXAA, for anti-
mesothelioma potential using the AE17-sOVA model that expresses ovalbumin (OVA) as a …

ATG5 as biomarker for early detection of malignant mesothelioma

M Tomasetti, F Monaco, O Strogovets, L Volpini… - BMC Research …, 2023 - Springer
Objectives Malignant pleural mesothelioma (MPM) is an aggressive disease with grim
prognosis due to lack of effective treatment options. Disease prediction in association with …

Analysis of new treatments proposed for malignant pleural mesothelioma raises concerns about the conduction of clinical trials in oncology

T Meirson, V Nardone, F Pentimalli, G Markel… - Journal of Translational …, 2022 - Springer
In this commentary, using existing clinical trial data and FDA approvals we propose that
there is currently a critical need for an appropriate balancing between the financial impact of …

Intratumor microbiota as a novel potential prognostic indicator in mesothelioma

F Pentimalli, M Krstic-Demonacos, C Costa… - Frontiers in …, 2023 - frontiersin.org
Introduction Despite increased attention on immunotherapy, primarily immune checkpoint
blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability …

Novel insights into mesothelioma therapy: emerging avenues and future prospects

L Kuryk, G Rodella, M Staniszewska, KW Pancer… - Frontiers in …, 2022 - frontiersin.org
Malignant mesothelioma is a rare and aggressive cancer that develops in the thin layer
surrounding the mesothelium and is mainly caused by asbestos exposure. Despite …

Effects of tumor-infiltrating CD8+ T cells, PD1/PD-L1 axis, and expression patterns of HLA class I on the prognosis of patients with malignant pleural mesothelioma …

R Okita, Y Mimura-Kimura, N Kawamoto… - Cancer Immunology …, 2023 - Springer
Programmed cell death protein-1 (PD1), PD1 ligand 1 (PD-L1), and human leukocyte
antigen (HLA) class I molecule play pivotal roles in T cell-induced anti-tumor immunity; …

Splicing deregulation, microRNA and notch aberrations: fighting the three-headed dog to overcome drug resistance in malignant mesothelioma

DP Anobile, G Montenovo, C Pecoraro… - Expert Review of …, 2022 - Taylor & Francis
ABSTRACT Introduction Malignant mesothelioma (MMe) is an aggressive rare cancer of the
mesothelium, associated with asbestos exposure. MMe is currently an incurable disease at …

Define the two molecular subtypes of epithelioid malignant pleural mesothelioma

UAK Saddozai, F Wang, S Khattak, MU Akbar, M Badar… - Cells, 2022 - mdpi.com
Malignant pleural mesothelioma (MPM) is a fatal disease of respiratory system. Despite the
availability of invasive biomarkers with promising results, there are still significant diagnostic …