Pleural mesothelioma (PMe): The evolving molecular knowledge of a rare and aggressive cancer
M Rigon, L Mutti, M Campanella - Molecular Oncology, 2024 - Wiley Online Library
Mesothelioma is a type of late‐onset cancer that develops in cells covering the outer surface
of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining …
of organs. Although it can affect the peritoneum, heart, or testicles, it mainly targets the lining …
Immune checkpoint inhibitors in malignant pleural mesothelioma: a systematic review and meta-analysis
Simple Summary Many clinical trials have investigated the role of Immune Checkpoint
Inhibitors (ICIs) in pleural mesothelioma (PM), with contrasting results. We performed a …
Inhibitors (ICIs) in pleural mesothelioma (PM), with contrasting results. We performed a …
The STING agonist, DMXAA, reduces tumor vessels and enhances mesothelioma tumor antigen presentation yet blunts cytotoxic T cell function in a murine model
PT Graham, AK Nowak, SMJ Cornwall, I Larma… - Frontiers in …, 2022 - frontiersin.org
We assessed the murine Stimulator of Interferon Genes (STING) agonist, DMXAA, for anti-
mesothelioma potential using the AE17-sOVA model that expresses ovalbumin (OVA) as a …
mesothelioma potential using the AE17-sOVA model that expresses ovalbumin (OVA) as a …
ATG5 as biomarker for early detection of malignant mesothelioma
M Tomasetti, F Monaco, O Strogovets, L Volpini… - BMC Research …, 2023 - Springer
Objectives Malignant pleural mesothelioma (MPM) is an aggressive disease with grim
prognosis due to lack of effective treatment options. Disease prediction in association with …
prognosis due to lack of effective treatment options. Disease prediction in association with …
Analysis of new treatments proposed for malignant pleural mesothelioma raises concerns about the conduction of clinical trials in oncology
In this commentary, using existing clinical trial data and FDA approvals we propose that
there is currently a critical need for an appropriate balancing between the financial impact of …
there is currently a critical need for an appropriate balancing between the financial impact of …
Intratumor microbiota as a novel potential prognostic indicator in mesothelioma
F Pentimalli, M Krstic-Demonacos, C Costa… - Frontiers in …, 2023 - frontiersin.org
Introduction Despite increased attention on immunotherapy, primarily immune checkpoint
blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability …
blockade, as a therapeutic approach for mesothelioma (MMe), its efficacy and tolerability …
Novel insights into mesothelioma therapy: emerging avenues and future prospects
L Kuryk, G Rodella, M Staniszewska, KW Pancer… - Frontiers in …, 2022 - frontiersin.org
Malignant mesothelioma is a rare and aggressive cancer that develops in the thin layer
surrounding the mesothelium and is mainly caused by asbestos exposure. Despite …
surrounding the mesothelium and is mainly caused by asbestos exposure. Despite …
Effects of tumor-infiltrating CD8+ T cells, PD1/PD-L1 axis, and expression patterns of HLA class I on the prognosis of patients with malignant pleural mesothelioma …
R Okita, Y Mimura-Kimura, N Kawamoto… - Cancer Immunology …, 2023 - Springer
Programmed cell death protein-1 (PD1), PD1 ligand 1 (PD-L1), and human leukocyte
antigen (HLA) class I molecule play pivotal roles in T cell-induced anti-tumor immunity; …
antigen (HLA) class I molecule play pivotal roles in T cell-induced anti-tumor immunity; …
Splicing deregulation, microRNA and notch aberrations: fighting the three-headed dog to overcome drug resistance in malignant mesothelioma
DP Anobile, G Montenovo, C Pecoraro… - Expert Review of …, 2022 - Taylor & Francis
ABSTRACT Introduction Malignant mesothelioma (MMe) is an aggressive rare cancer of the
mesothelium, associated with asbestos exposure. MMe is currently an incurable disease at …
mesothelium, associated with asbestos exposure. MMe is currently an incurable disease at …
Define the two molecular subtypes of epithelioid malignant pleural mesothelioma
Malignant pleural mesothelioma (MPM) is a fatal disease of respiratory system. Despite the
availability of invasive biomarkers with promising results, there are still significant diagnostic …
availability of invasive biomarkers with promising results, there are still significant diagnostic …