Immune tolerance hinders the potentially destructive responses of lymphocytes to host
tissues. Tolerance is regulated at the stage of immature B cell development (central …

Abstract Type 1 Diabetes (T1D) is an autoimmune disease characterized by the pancreatic
infiltration of immune cells resulting in T cell-mediated destruction of the insulin-producing …

Tissue-specific autoimmune diseases are driven by activation of diverse immune cells in the
target organs. However, the molecular signatures of immune cell populations over time in an …

Although dogma predicts that under normal circumstances, potentially offensive autoreactive
cells are silenced by mechanisms of immune tolerance, islet antigen–reactive B …

Purpose Autosomal recessive deficiencies of DNMT3B or ZBTB24 account for two-thirds of
cases of immunodeficiency, centromeric instability and facial dysmorphism (ICF syndrome) …

Autoantibodies to insulin are a harbinger of autoimmunity in type 1 diabetes in humans and
in non-obese diabetic mice. To understand the genesis of these autoantibodies, we …

Early breaches in B cell tolerance are central to type 1 diabetes progression in mouse and
man. Conventional BCR transgenic mouse models (VH125. Tg NOD) reveal the power of B …

JJ Ratiu and JJ Racine designed and conducted experiments, interpreted data, and
contributed to writing of the manuscript; MGH designed and conducted experiments and …

Pancreatic islet-reactive B lymphocytes promote Type 1 diabetes (T1D) by presenting an
antigen to islet-destructive T cells. Teplizumab, an anti-CD3 monoclonal, delays T1D onset …

Abstract Type 1 diabetes (T1D) affects over a million Americans, and disease incidence is
on the rise. Despite decades of research, there is still no cure for this disease. Exciting beta …