The changing paradigm of drug-resistant tuberculosis treatment: successes, pitfalls, and future perspectives

N Dookie, SL Ngema, R Perumal… - Clinical Microbiology …, 2022 - Am Soc Microbiol
Drug-resistant tuberculosis (DR-TB) remains a global crisis due to the increasing incidence
of drug-resistant forms of the disease, gaps in detection and prevention, models of care, and …

Delamanid: from discovery to its use for pulmonary multidrug-resistant tuberculosis (MDR-TB)

Y Liu, M Matsumoto, H Ishida, K Ohguro, M Yoshitake… - Tuberculosis, 2018 - Elsevier
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is the leading cause of
death from an infectious disease globally. The widespread and ever-increasing resistance to …

Regimens to treat multidrug-resistant tuberculosis: past, present and future perspectives

E Pontali, MC Raviglione… - European Respiratory …, 2019 - Eur Respiratory Soc
Over the past few decades, treatment of multidrug-resistant (MDR)/extensively drug-resistant
(XDR) tuberculosis (TB) has been challenging because of its prolonged duration (up to 20 …

Bedaquiline and delamanid in the treatment of multidrug‐resistant tuberculosis: Promising but challenging

Y Li, F Sun, W Zhang - Drug development research, 2019 - Wiley Online Library
Improving treatment outcomes in multidrug‐resistant tuberculosis (MDR‐TB) is partly
hampered by inadequate effective antitubercular agents. Development of bedaquiline and …

[HTML][HTML] The struggle to end a millennia-long pandemic: novel candidate and repurposed drugs for the treatment of tuberculosis

BD Edwards, SK Field - Drugs, 2022 - Springer
This article provides an encompassing review of the current pipeline of putative and
developed treatments for tuberculosis, including multidrug-resistant strains. The review has …

[HTML][HTML] Delamanid-containing regimens and multidrug-resistant tuberculosis: A systematic review and meta-analysis

MJ Nasiri, M Zangiabadian, E Arabpour, S Amini… - International Journal of …, 2022 - Elsevier
Introduction Multidrug-resistant tuberculosis (MDR-TB) is a life-threatening condition
needing long poly-chemotherapy regimens. As no systematic reviews/meta-analysis is …

Туберкулез с множественной лекарственной устойчивостью возбудителя в странах мираи в российской федерации

ИА Васильева, ЕМ Белиловский… - … и болезни легких, 2017 - tibl-journal.com
Аннотация В статье представлены сведения о распространении туберкулеза с
МЛУ/РУ/ШЛУ в странах мира и регионах ВОЗ в сравнении с Российской Федерацией …

New and repurposed drugs for the treatment of active tuberculosis: an update for clinicians

JM Aguilar Diaz, AA Abulfathi, LH Te Brake… - Respiration, 2023 - karger.com
Although tuberculosis (TB) is preventable and curable, the lengthy treatment (generally 6
months), poor patient adherence, high inter-individual variability in pharmacokinetics (PK) …

Bedaquiline and delamanid for the treatment of multidrug-resistant tuberculosis: a multicentre cohort study in Korea

CT Kim, TO Kim, HJ Shin, YC Ko… - European …, 2018 - Eur Respiratory Soc
Relatively little is known about the efficacy and safety of the programmatic use of
bedaquiline and delamanid in multidrug-resistant tuberculosis (MDR-TB) treatment. This …

[HTML][HTML] Bedaquiline and Linezolid improve anti-TB treatment outcome in drug-resistant TB patients with HIV: A systematic review and meta-analysis

Y Wu, Y Zhang, Y Wang, J Wei, W Wang… - Pharmacological …, 2022 - Elsevier
Objectives We aimed to assess the effect of second-line anti-TB treatment and determine
which drugs can achieve the greatest clinical benefit for DR-TB-HIV patients by comparing …