Predicting tumour radiosensitivity to deliver precision radiotherapy

JM Price, A Prabhakaran, CML West - Nature Reviews Clinical …, 2023 - nature.com
Owing to advances in radiotherapy, the physical properties of radiation can be optimized to
enable individualized treatment; however, optimization is rarely based on biological …

[HTML][HTML] PI3K/AKT/mTOR signaling pathway in HPV-driven head and neck carcinogenesis: therapeutic implications

F Aguayo, F Perez-Dominguez, JC Osorio, C Oliva… - Biology, 2023 - mdpi.com
Simple Summary A subgroup of cancers that arises in the zone of the head and neck
(HNCs) are caused by some types of human papillomavirus (HPV), so called high-risk (HR) …

[HTML][HTML] Genomic signatures in HPV-associated tumors

SS Hussain, D Lundine, JE Leeman, DS Higginson - Viruses, 2021 - mdpi.com
Papillomaviruses dysregulate the G1/S cell cycle transition in order to promote DNA
synthesis in S phase, which is a requirement for viral replication. The human …

[HTML][HTML] Multifactorial model based on DWI-radiomics to determine HPV status in oropharyngeal squamous cell carcinoma

S Marzi, F Piludu, I Avanzolini, V Muneroni… - Applied Sciences, 2022 - mdpi.com
Featured Application Imaging-based predictors of HPV status could be used to non-
invasively detect HPV positivity in cases in which biopsy is not feasible because of a hardly …

[HTML][HTML] Do we have enough evidence to specifically recommend transoral robotic surgery in HPV− Driven oropharyngeal cancer? A systematic review

A De Virgilio, A Costantino, D Rizzo, C Crescio… - Pathogens, 2023 - mdpi.com
Simple Summary The aim of the present study is to summarize the current evidence
published in the literature concerning the role of transoral robotic surgery in HPV+ …

[HTML][HTML] Hypoxia Modulates Radiosensitivity and Response to Different Radiation Qualities in A549 Non-Small Cell Lung Cancer (NSCLC) Cells

H Nisar, FM Labonté, MD Roggan, C Schmitz… - International Journal of …, 2024 - mdpi.com
Hypoxia-induced radioresistance reduces the efficacy of radiotherapy for solid
malignancies, including non-small cell lung cancer (NSCLC). Cellular hypoxia can confer …

[HTML][HTML] High-dose loco-regional pattern of failure after primary radiotherapy in p16 positive and negative head and neck squamous cell carcinoma–A DAHANCA 19 …

MH Kristensen, AIS Holm, CR Hansen… - Clinical and translational …, 2024 - Elsevier
Introduction Patients with failure after primary radiotherapy (RT) for head and neck
squamous cell carcinoma (HNSCC) have a poor prognosis. This study investigates pattern …

[HTML][HTML] Mechanisms involved in cancer stem cell resistance in head and neck squamous cell carcinoma

JM Siqueira, D Heguedusch, CO Rodini… - Cancer Drug …, 2023 - ncbi.nlm.nih.gov
Despite scientific advances in the Oncology field, cancer remains a leading cause of death
worldwide. Molecular and cellular heterogeneity of head and neck squamous cell carcinoma …

[HTML][HTML] Moving from conventional to adaptive risk stratification for oropharyngeal cancer

VC Sandulache, RP Kirby, SY Lai - Frontiers in Oncology, 2024 - frontiersin.org
Oropharyngeal cancer (OPC) poses a complex therapeutic dilemma for patients and
oncologists alike, made worse by the epidemic increase in new cases associated with the …

Survival benefits of human papillomavirus 16 infection in patients with esophageal squamous cell carcinoma undergoing chemoradiotherapy: A retrospective cohort …

F Qu, C Ji, Y Wang, R Zhu, W Hu, S Liu… - Journal of Medical …, 2024 - Wiley Online Library
The role of human papillomavirus 16 (HPV 16) in esophageal squamous cell carcinoma
(ESCC) remains uncertain. Therefore, this study aimed to investigate the prevalence of HPV …