Metabolic adaptations in the brain are critical to the establishment and maintenance of
normal cellular functions and to the pathological responses to disease processes. Here, we …

This chapter reviews the basis of brain interstitial fluid homeostasis and discusses the roles
of the glymphatic system in the clearance of fluid and solutes. The anatomical organization …

Background: Sleep disturbance may affect the development of Alzheimer's disease (AD), but
the neural correlates of sleep disturbance in AD have not been fully clarified. Objective: To …

Recent evidence showed that EEG activity alterations that occur during sleep are associated
with structural, age-related, changes in healthy aging brains, and predict age-related decline …

Sleep stages classification is an effective tool for the diagnosis and treatment of
neurodegenerative disorders. This paper presents the first non-invasive …

Sleep is essential for our physical and mental well-being. During sleep, despite the paucity
of overt behavior, our brain remains active and exhibits a wide range of coupled brain …

The development of therapeutics for central nervous system (CNS) disorders has many
challenges that result in low probability of success and longer-than-typical development …

Neuropsychiatric disturbances (NPDs) are considered hallmarks of Alzheimer's disease
(AD). Nevertheless, treatment of these symptoms has proven difficult and development of …

Abstract Purpose of Review Sleep is a physiological process characterized by a crucial
interaction between behavioural and neurobiological aspects, thereby directly influencing …

Orexin is a novel neurotransmitter released from lateral hypothalamus, that is a crucial
modulator in sleep/wakefulness system. Recent studies also suggest its possible role in the …