Maternal immune activation and neuroinflammation in human neurodevelopmental disorders

VX Han, S Patel, HF Jones, RC Dale - Nature Reviews Neurology, 2021 - nature.com
Maternal health during pregnancy plays a major role in shaping health and disease risks in
the offspring. The maternal immune activation hypothesis proposes that inflammatory …

The gut microbiota–brain axis in behaviour and brain disorders

LH Morais, HL Schreiber IV… - Nature Reviews …, 2021 - nature.com
In a striking display of trans-kingdom symbiosis, gut bacteria cooperate with their animal
hosts to regulate the development and function of the immune, metabolic and nervous …

Perinatal mental health: a review of progress and challenges

LM Howard, H Khalifeh - World Psychiatry, 2020 - Wiley Online Library
Perinatal mental health has become a significant focus of interest in recent years, with
investment in new specialist mental health services in some high‐income countries, and …

Assessment of maternal and neonatal SARS-CoV-2 viral load, transplacental antibody transfer, and placental pathology in pregnancies during the COVID-19 …

AG Edlow, JZ Li, YC Ai-ris, C Atyeo, KE James… - JAMA network …, 2020 - jamanetwork.com
Importance Biological data are lacking with respect to risk of vertical transmission and
mechanisms of fetoplacental protection in maternal severe acute respiratory syndrome …

[HTML][HTML] The role of short-chain fatty acids from gut microbiota in gut-brain communication

YP Silva, A Bernardi, RL Frozza - Frontiers in endocrinology, 2020 - frontiersin.org
A substantial body of evidence supports that the gut microbiota plays a pivotal role in the
regulation of metabolic, endocrine and immune functions. In recent years, there has been …

Maternal acute and chronic inflammation in pregnancy is associated with common neurodevelopmental disorders: a systematic review

VX Han, S Patel, HF Jones, TC Nielsen… - Translational …, 2021 - nature.com
Inflammation is increasingly recognized as a cause or consequence of common problems of
humanity including obesity, stress, depression, pollution and disease states such as …

Innate immunity at the crossroads of healthy brain maturation and neurodevelopmental disorders

KE Zengeler, JR Lukens - Nature Reviews Immunology, 2021 - nature.com
The immune and nervous systems have unique developmental trajectories that individually
build intricate networks of cells with highly specialized functions. These two systems have …

Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …

Microglia emerge as central players in brain disease

MW Salter, B Stevens - Nature medicine, 2017 - nature.com
There has been an explosion of new findings recently giving us insights into the involvement
of microglia in central nervous system (CNS) disorders. A host of new molecular tools and …

Microglia and neurodevelopmental disorders

JR Lukens, UB Eyo - Annual review of neuroscience, 2022 - annualreviews.org
Mounting evidence indicates that microglia, which are the resident immune cells of the brain,
play critical roles in a diverse array of neurodevelopmental processes required for proper …