Background Inflammation in the lung is the body's natural response to injury. It acts to
remove harmful stimuli such as pathogens, irritants, and damaged cells and initiate the …

Sepsis represents the host's systemic inflammatory response to a severe infection. It causes
substantial human morbidity resulting in hundreds of thousands of deaths each year …

Sepsis involves the dynamic interplay between a pathogen, the host response, the failure of
organ systems, medical interventions and a myriad of other factors. This together results in a …

Multiscale systems biology and systems pharmacology are powerful methodologies that are
playing increasingly important roles in understanding the fundamental mechanisms of …

Simulations of tissue-specific effects of primary acute viral infections like COVID-19 are
essential for understanding disease outcomes and optimizing therapies. Such simulations …

Several components that interact with each other to evolve a complex, and, in some cases,
unexpected behavior, represents one of the main and fascinating features of the mammalian …

Technology in bioanalysis,-omics, and computation have evolved over the past half century
to allow for comprehensive assessments of the molecular to whole body pharmacology of …

Pathogenic microorganisms entail enormous problems for humans, livestock, and crop
plants. A better understanding of the different infection strategies of the pathogens enables …

A timely guide using iterative learning control (ILC) as a solution for multi-agent systems
(MAS) challenges, showcasing recent advances and industrially relevant applications …

Objectives: To familiarize clinicians with advances in computational disease modeling
applied to trauma and sepsis. Data Sources: PubMed search and review of relevant medical …