Brain glucose metabolism: integration of energetics with function

GA Dienel - Physiological reviews, 2019 - journals.physiology.org
Glucose is the long-established, obligatory fuel for brain that fulfills many critical functions,
including ATP production, oxidative stress management, and synthesis of neurotransmitters …

Integration of GC–MS and LC–MS for untargeted metabolomics profiling

ÖC Zeki, CC Eylem, T Reçber, S Kır… - Journal of Pharmaceutical …, 2020 - Elsevier
Recently, metabolomics analyses have become increasingly common in the general
scientific community as it is applied in several researches relating to diseases diagnosis …

Biomarkers used in Alzheimer's disease diagnosis, treatment, and prevention

YAR Mahaman, KS Embaye, F Huang, L Li, F Zhu… - Ageing research …, 2022 - Elsevier
Abstract Alzheimer's disease (AD), being the number one in terms of dementia burden, is an
insidious age-related neurodegenerative disease and is presently considered a global …

Glutamate and GABA in microglia-neuron cross-talk in Alzheimer's disease

GA Czapski, JB Strosznajder - International Journal of Molecular Sciences, 2021 - mdpi.com
The physiological balance between excitation and inhibition in the brain is significantly
affected in Alzheimer's disease (AD). Several neuroactive compounds and their signaling …

Omics sciences for systems biology in Alzheimer's disease: State-of-the-art of the evidence

H Hampel, R Nisticò, NT Seyfried, AI Levey… - Ageing Research …, 2021 - Elsevier
Alzheimer's disease (AD) is characterized by non-linear, genetic-driven pathophysiological
dynamics with high heterogeneity in biological alterations and disease spatial-temporal …

Altered bile acid profile in mild cognitive impairment and Alzheimer's disease: relationship to neuroimaging and CSF biomarkers

K Nho, A Kueider-Paisley… - Alzheimer's & …, 2019 - Elsevier
Abstract Introduction Bile acids (BAs) are the end products of cholesterol metabolism
produced by human and gut microbiome co-metabolism. Recent evidence suggests gut …

[HTML][HTML] Anti-oxidant and anti-inflammatory activity of ketogenic diet: new perspectives for neuroprotection in Alzheimer's disease

A Pinto, A Bonucci, E Maggi, M Corsi, R Businaro - Antioxidants, 2018 - mdpi.com
The ketogenic diet, originally developed for the treatment of epilepsy in non-responder
children, is spreading to be used in the treatment of many diseases, including Alzheimer's …

Integrative metabolomics‐genomics approach reveals key metabolic pathways and regulators of Alzheimer's disease

E Horgusluoglu, R Neff, WM Song… - Alzheimer's & …, 2022 - Wiley Online Library
Metabolites, the biochemical products of the cellular process, can be used to measure
alterations in biochemical pathways related to the pathogenesis of Alzheimer's disease …

[HTML][HTML] Phytochemicals and cognitive health: Are flavonoids doing the trick?

I Bakoyiannis, A Daskalopoulou, V Pergialiotis… - Biomedicine & …, 2019 - Elsevier
Flavonoids constitute a large group of polyphenolic compounds with numerous effects on
behaviour and cognition. These effects vary from learning and memory enhancement to an …

Current aspects of the endocannabinoid system and targeted THC and CBD phytocannabinoids as potential therapeutics for Parkinson's and Alzheimer's diseases: a …

R Cooray, V Gupta, C Suphioglu - Molecular neurobiology, 2020 - Springer
Neurodegeneration leading to Parkinson's disease (PD) and Alzheimer's disease (AD) has
become a major health burden globally. Current treatments mainly target controlling …