Sepsis is a life-threatening clinical syndrome characterized by multiorgan dysfunction
caused by a dysregulated or over-reactive host response to infection. During sepsis, the …

The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Rationale: In addition to the overwhelming lung inflammation that prevails in coronavirus
disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of …

Sepsis is characterized by a dysregulated immune response to infections that causes life-
threatening organ dysfunction and even death. When infections occur, bacterial cell wall …

COVID-19 pandemia is a major health emergency causing hundreds of deaths worldwide.
The high reported morbidity has been related to hypoxia and inflammation leading to …

Tissue injury can drive secondary organ injury; however, mechanisms and mediators are not
well understood. To identify interorgan cross-talk mediators, we used acute kidney injury …

Sepsis is a disease characterized by multiple organ failure caused by immune
hyperactivation and cytokine storms. Studies have shown that the incidence of sepsis in …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …

Background Degradation of the endothelial glycocalyx is critical for sepsis-associated lung
injury and pulmonary vascular permeability. We investigated whether sulodexide, a …

The maintenance of the physiological values of blood pressure is closely related to
unchangeable factors (genetic predisposition or pathological alterations) but also to …