Introduction Endothelial cells maintain vascular integrity, tone, and patency and have
important roles in hemostasis and inflammatory responses. Although some degree of …

Sepsis is defined as a dysregulated host response leading to organ dysfunction, which may
ultimately result in the patient's death. Mitochondrial dysfunction plays a key role in …

Sepsis, a severe systemic inflammatory response to infection, remains a leading cause of
morbidity and mortality worldwide. Exosomes, as mediators of intercellular communication …

Acute lung injury (ALI) is a frequent and challenging aspect of sepsis that currently lacks
effective treatments. Procyanidin B2 (PB2) has anti-inflammatory and antioxidant properties …

Background Positive fluid balance and tissue fluid accumulation are associated with
adverse outcomes in sepsis. Vascular endothelial growth factor (VEGF) increases in sepsis …

Endothelial dysfunction leading to vascular permeability and plasma leakage are
characteristic features of severe dengue and sepsis. However, the mechanisms underlying …

(1) Background. Repetitive animal studies that have disappointed upon translation into
clinical therapies have led to an increased appreciation of humanized mice as a remedy to …

Fluid resuscitation is an essential intervention in critically ill patients, and its ultimate goal is
to restore tissue perfusion. Critical illnesses are often accompanied by glycocalyx …

While the role of dysregulated polymorphonuclear leukocyte (PMN) transmigration in septic
mediated tissue damage is well documented, strategies to mitigate aberrant transmigration …

Sepsis is a dysregulated host response to an infection, characterized by organ failure. The
pathophysiology is complex and incompletely understood, but mitochondria appear to play a …