Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

Chemical modifications on mRNA represent a critical layer of gene expression regulation.
Research in this area has continued to accelerate over the last decade, as more …

The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …

RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

Abstract Crick's Central Dogma has been a foundational aspect of 20th century biology,
describing an implicit relationship governing the flow of information in biological systems in …

Triple-negative breast cancer (TNBC), although highly lethal, lacks validated therapeutic
targets. Here, we report that U2 snRNP-associated SURP motif-containing protein …

Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …

The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been
found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer …

Proteins provide the basis for cellular function. Having multiple versions of the same protein
within a single organism provides a way of regulating its activity or developing novel …