The physiology of alternative splicing

LE Marasco, AR Kornblihtt - Nature Reviews Molecular Cell Biology, 2023 - nature.com
Alternative splicing is a substantial contributor to the high complexity of transcriptomes of
multicellular eukaryotes. In this Review, we discuss the accumulated evidence that most of …

mRNA regulation by RNA modifications

WV Gilbert, S Nachtergaele - Annual Review of Biochemistry, 2023 - annualreviews.org
Chemical modifications on mRNA represent a critical layer of gene expression regulation.
Research in this area has continued to accelerate over the last decade, as more …

Regulation of pre-mRNA splicing: roles in physiology and disease, and therapeutic prospects

ME Rogalska, C Vivori, J Valcárcel - Nature Reviews Genetics, 2023 - nature.com
The removal of introns from mRNA precursors and its regulation by alternative splicing are
key for eukaryotic gene expression and cellular function, as evidenced by the numerous …

[PDF][PDF] hdWGCNA identifies co-expression networks in high-dimensional transcriptomics data

S Morabito, F Reese, N Rahimzadeh, E Miyoshi… - Cell reports …, 2023 - cell.com
Biological systems are immensely complex, organized into a multi-scale hierarchy of
functional units based on tightly regulated interactions between distinct molecules, cells …

The nexus between RNA-binding proteins and their effectors

S He, E Valkov, S Cheloufi, J Murn - Nature Reviews Genetics, 2023 - nature.com
RNA-binding proteins (RBPs) regulate essentially every event in the lifetime of an RNA
molecule, from its production to its destruction. Whereas much has been learned about RNA …

A revised central dogma for the 21st century: All biology is cognitive information processing

WB Miller Jr, F Baluška, AS Reber - Progress in Biophysics and Molecular …, 2023 - Elsevier
Abstract Crick's Central Dogma has been a foundational aspect of 20th century biology,
describing an implicit relationship governing the flow of information in biological systems in …

MYC-driven U2SURP regulates alternative splicing of SAT1 to promote triple-negative breast cancer progression

L Deng, L Liao, YL Zhang, SY Hu, SY Yang, XY Ma… - Cancer Letters, 2023 - Elsevier
Triple-negative breast cancer (TNBC), although highly lethal, lacks validated therapeutic
targets. Here, we report that U2 snRNP-associated SURP motif-containing protein …

Comprehensive isoform-level analysis reveals the contribution of alternative isoforms to venom evolution and repertoire diversity

X Ye, C He, Y Yang, YH Sun, S Xiong… - Genome …, 2023 - genome.cshlp.org
Animal venom systems have emerged as valuable models for investigating how novel
polygenic phenotypes may arise from gene evolution by varying molecular mechanisms …

[HTML][HTML] Anti-HERV-K drugs and vaccines, possible therapies against tumors

S Hosseiniporgham, LA Sechi - Vaccines, 2023 - mdpi.com
The footprint of human endogenous retroviruses (HERV), specifically HERV-K, has been
found in malignancies, such as melanoma, teratocarcinoma, osteosarcoma, breast cancer …

[HTML][HTML] Protein diversification through post-translational modifications, alternative splicing, and gene duplication

Y Goldtzvik, N Sen, SD Lam, C Orengo - Current Opinion in Structural …, 2023 - Elsevier
Proteins provide the basis for cellular function. Having multiple versions of the same protein
within a single organism provides a way of regulating its activity or developing novel …