Tumour progression is modulated by the local microenvironment. This environment is
populated by many immune cells, of which macrophages are among the most abundant …

Neutrophils are the first responders to infection and inflammation and are thus a critical
component of innate immune defense. Understanding the behavior of neutrophils as they …

Macrophage polarization refers to how macrophages have been activated at a given point in
space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate …

Granulocyte–macrophage colony-stimulating factor (GM-CSF) has many more functions
than its original in vitro identification as an inducer of granulocyte and macrophage …

Metastatic disease remains the primary cause of death for patients with breast cancer. The
different steps of the metastatic cascade rely on reciprocal interactions between cancer cells …

Macrophages are very important in the pathogenesis of rheumatoid arthritis (RA). The
increase in the number of sublining macrophages in the synovium is an early hallmark of …

Abstract M-CSF and GM-CSF are 2 important cytokines that regulate macrophage numbers
and function. Here, we review their known effects on cells of the macrophage-monocyte …

Long recognized as an evolutionarily ancient cell type involved in tissue homeostasis and
immune defense against pathogens, macrophages are being rediscovered as regulators of …

Macrophage infiltration has been identified as an independent poor prognostic factor in
several cancer types. The major survival factor for these macrophages is macrophage …

Macrophages, the most plastic cells of the haematopoietic system, are found in all tissues
and show great functional diversity. They have roles in development, homeostasis, tissue …