[HTML][HTML] European Headache Federation guideline on the use of monoclonal antibodies targeting the calcitonin gene related peptide pathway for migraine prevention …
Abstract Background A previous European Headache Federation (EHF) guideline
addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide …
addressed the use of monoclonal antibodies targeting the calcitonin gene-related peptide …
US FDA approved drugs from 2015–June 2020: a perspective
In the present work, we report compilation and analysis of 245 drugs, including small and
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
macromolecules approved by the US FDA from 2015 until June 2020. Nearly 29% of the …
CGRP physiology, pharmacology, and therapeutic targets: migraine and beyond
Calcitonin gene-related peptide (CGRP) is a neuropeptide with diverse physiological
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
functions. Its two isoforms (α and β) are widely expressed throughout the body in sensory …
Amide bond bioisosteres: Strategies, synthesis, and successes
The amide functional group plays a key role in the composition of biomolecules, including
many clinically approved drugs. Bioisosterism is widely employed in the rational …
many clinically approved drugs. Bioisosterism is widely employed in the rational …
Somatosensory and autonomic neuronal regulation of the immune response
S Udit, K Blake, IM Chiu - Nature Reviews Neuroscience, 2022 - nature.com
Bidirectional communication between the peripheral nervous system (PNS) and the immune
system is a crucial part of an effective but balanced mammalian response to invading …
system is a crucial part of an effective but balanced mammalian response to invading …
CGRP as the target of new migraine therapies—successful translation from bench to clinic
L Edvinsson, KA Haanes, K Warfvinge… - Nature Reviews …, 2018 - nature.com
Abstract Treatment of migraine is on the cusp of a new era with the development of drugs
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …
that target the trigeminal sensory neuropeptide calcitonin gene-related peptide (CGRP) or its …
CGRP and the trigeminal system in migraine
S Iyengar, KW Johnson, MH Ossipov… - … : The Journal of Head …, 2019 - Wiley Online Library
Objective The goal of this narrative review is to provide an overview of migraine
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
pathophysiology, with an emphasis on the role of calcitonin gene‐related peptide (CGRP) …
[HTML][HTML] Schwann cell endosome CGRP signals elicit periorbital mechanical allodynia in mice
F De Logu, R Nassini, A Hegron, L Landini… - Nature …, 2022 - nature.com
Efficacy of monoclonal antibodies against calcitonin gene-related peptide (CGRP) or its
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …
receptor (calcitonin receptor-like receptor/receptor activity modifying protein-1, CLR/RAMP1) …
[HTML][HTML] Pathophysiology of migraine: a disorder of sensory processing
PJ Goadsby, PR Holland… - Physiological …, 2017 - journals.physiology.org
Plaguing humans for more than two millennia, manifest on every continent studied, and with
more than one billion patients having an attack in any year, migraine stands as the sixth …
more than one billion patients having an attack in any year, migraine stands as the sixth …
Pain and immunity: implications for host defence
Pain is a hallmark of tissue injury, inflammatory diseases, pathogen invasion and
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …
neuropathy. It is mediated by nociceptor sensory neurons that innervate the skin, joints …