The innervation of bone has been described for centuries, and our understanding of its
function has rapidly evolved over the past several decades to encompass roles of subtype …

The neuronal engagement of the peripheral nerve system plays a crucial role in regulating
fracture healing, but how to modulate the neuronal activity to enhance fracture healing …

Adipose tissue comprises adipocytes and many other cell types that engage in dynamic
crosstalk in a highly innervated and vascularized tissue matrix. Although adipose tissue has …

G protein–coupled receptors (GPCRs) are the largest family of cell surface receptors. Class
B1 GPCRs constitute a subfamily of 15 receptors that characteristically contain large …

Migraine is a common neurological disorder that afflicts up to 15% of the adult population in
most countries, with predominance in females. It is characterized by episodic, often disabling …

Neuroimmune interactions have emerged as critical modulators of allergic inflammation, and
type 2 innate lymphoid cells (ILC2s) are an important cell type for mediating these …

G protein-coupled receptors (GPCRs) are known to interact with several other classes of
integral membrane proteins that modulate their biology and pharmacology. However, the …

Although the medical definition of itch has been in existence for 360 years, only in the last 20
years have we begun to understand the basic mechanisms that underlie this unique …

Objective Calcitonin gene–related peptide (CGRP) pathway inhibitors are emerging
treatments for migraine. CGRP‐mediated vasodilation is, however, a critical rescue …

Allergic conjunctivitis is a chronic inflammatory disease that is characterized by severe itch
in the conjunctiva, but how neuro-immune interactions shape the pathogenesis of severe …