[HTML][HTML] Strengthening cardiac therapy pipelines using human pluripotent stem cell-derived cardiomyocytes
K Raniga, A Nasir, NTN Vo, R Vaidyanathan… - Cell Stem Cell, 2024 - cell.com
Advances in hiPSC isolation and reprogramming and hPSC-CM differentiation have
prompted their therapeutic application and utilization for evaluating potential cardiovascular …
prompted their therapeutic application and utilization for evaluating potential cardiovascular …
In vitro and In silico Models to Study SARS-CoV-2 Infection: Integrating Experimental and Computational Tools to Mimic “COVID-19 Cardiomyocyte”
R Dariolli, C Campana, A Gutierrez… - Frontiers in Physiology, 2021 - frontiersin.org
The rapid dissemination of SARS-CoV-2 has made COVID-19 a tremendous social,
economic, and health burden. Despite the efforts to understand the virus and treat the …
economic, and health burden. Despite the efforts to understand the virus and treat the …
Parallel space-time adaptive numerical simulation of 3d cardiac electrophysiology
N Chamakuri, P Kügler - Applied Numerical Mathematics, 2022 - Elsevier
The bidomain equations form the state-of-the-art model of cardiac electrophysiology and
describe normal or pathological propagation of the excitation wave through cardiac tissue. If …
describe normal or pathological propagation of the excitation wave through cardiac tissue. If …
Artificial Intelligence-Driven Algorithm for Drug Effect Prediction on Atrial Fibrillation: An in silico Population of Models Approach
AM Sanchez de la Nava, Á Arenal… - Frontiers in …, 2021 - frontiersin.org
Background: Antiarrhythmic drugs are the first-line treatment for atrial fibrillation (AF), but
their effect is highly dependent on the characteristics of the patient. Moreover, anatomical …
their effect is highly dependent on the characteristics of the patient. Moreover, anatomical …
Circadian rhythms of early afterdepolarizations and ventricular arrhythmias in a cardiomyocyte model
CO Diekman, N Wei - Biophysical Journal, 2021 - cell.com
Sudden cardiac arrest is a malfunction of the heart's electrical system, typically caused by
ventricular arrhythmias, that can lead to sudden cardiac death (SCD) within minutes …
ventricular arrhythmias, that can lead to sudden cardiac death (SCD) within minutes …
[HTML][HTML] Electro-anatomical computational cardiology in humans and experimental animal models
SR Kharche, R Mudathir, CW McIntyre - Translational Research in …, 2022 - Elsevier
Background A significant proportion of the world population suffer from cardiac arrythmia
that lead to arrest, sudden cardiac death, and often a severely reduced quality of life post …
that lead to arrest, sudden cardiac death, and often a severely reduced quality of life post …
From multiscale biophysics to digital twins of tissues and organs: future opportunities for in-silico pharmacology
MT Barros, M Paci, A Tervonen… - … Biological, and Multi …, 2024 - ieeexplore.ieee.org
With many advancements in in silico multiscale biology in recent years, the paramount
challenge is to translate the accumulated knowledge into exciting industry partnerships and …
challenge is to translate the accumulated knowledge into exciting industry partnerships and …
Definition of a sensitivity profile for drug treatment and identification on clinical biomarkers in atrial fibrillation
AM Sánchez de la Nava - 2022 - riunet.upv.es
[EN] Atrial Fibrillation (AF) is one of the most common arrhythmias in clinical practice and
thus far, the electrophysiological mechanisms underlying its initiation and maintenance are …
thus far, the electrophysiological mechanisms underlying its initiation and maintenance are …
[HTML][HTML] Numerical Simulation of a Physiological Mathematical Model of Energy Consumption in a Sarcomere
KG Flores-Rodríguez, DE Pérez-Garza… - Revista mexicana de …, 2021 - scielo.org.mx
The paradigm of biological systems provides a framework to quantify the behavior of
biological processes. Mathematical modeling is one of the analytical tools of biological …
biological processes. Mathematical modeling is one of the analytical tools of biological …
Simplification of weakly nonlinear systems and analysis of cardiac activity using them.
I Dzhalladova, M Růžičková - Discrete & Continuous …, 2022 - search.ebscohost.com
The paper deals with the transformation of a weakly nonlinear system of differential
equations in a special form into a simplified form and its relation to the normal form and …
equations in a special form into a simplified form and its relation to the normal form and …