Fluorination methods in drug discovery
Fluorination reactions of medicinal and biologically-active compounds will be discussed.
Late stage fluorination strategies of medicinal targets have recently attracted considerable …
Late stage fluorination strategies of medicinal targets have recently attracted considerable …
Chlorinated solvents: their advantages, disadvantages, and alternatives in organic and medicinal chemistry
A Jordan, P Stoy, HF Sneddon - Chemical Reviews, 2020 - ACS Publications
Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and
Medicinal Chemistry | Chemical Reviews ACS ACS Publications C&EN CAS Find my …
Medicinal Chemistry | Chemical Reviews ACS ACS Publications C&EN CAS Find my …
Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF
C Patel, E André-Joyaux, JA Leitch… - Science, 2023 - science.org
All fluorochemicals—including elemental fluorine and nucleophilic, electrophilic, and radical
fluorinating reagents—are prepared from hydrogen fluoride (HF). This highly toxic and …
fluorinating reagents—are prepared from hydrogen fluoride (HF). This highly toxic and …
Where does the fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds
S Caron - Organic Process Research & Development, 2020 - ACS Publications
Fluorinated organic molecules are increasingly being prepared for a variety of applications,
including pharmaceutical products. However, the supply chain to access the necessary raw …
including pharmaceutical products. However, the supply chain to access the necessary raw …
Application of metal oxide semiconductors in light-driven organic transformations
The search for greener alternatives to perform organic reactions has become the order of the
day in the chemistry community. In this regard, the use of heterogeneous photocatalysts has …
day in the chemistry community. In this regard, the use of heterogeneous photocatalysts has …
Repurposing of F-gases: challenges and opportunities in fluorine chemistry
DJ Sheldon, MR Crimmin - Chemical Society Reviews, 2022 - pubs.rsc.org
Fluorinated gases (F-gases) are routinely employed as refrigerants, blowing agents, and
electrical insulators. These volatile compounds are potent greenhouse gases and …
electrical insulators. These volatile compounds are potent greenhouse gases and …
Fluorine in the environment, a review of its sources and geochemistry
R Fuge - Applied Geochemistry, 2019 - Elsevier
While F is an essential constituent of some rock-forming minerals such as fluorite and
apatite, its major occurrence in the lithosphere is within hydroxysilicate minerals where F …
apatite, its major occurrence in the lithosphere is within hydroxysilicate minerals where F …
Electrooxidative dearomatization of biaryls: synthesis of tri-and difluoromethylated spiro [5.5] trienones
Y Zhang, C Ma, J Struwe, J Feng, G Zhu… - Chemical …, 2021 - pubs.rsc.org
Radical spirocyclization via dearomatization has emerged as an attractive strategy for the
rapid synthesis of structurally diverse spiro molecules. We report the use of electrochemistry …
rapid synthesis of structurally diverse spiro molecules. We report the use of electrochemistry …
Fluorination and fluoroalkylation of alkenes/alkynes to construct fluoro-containing heterocycles
X Wang, J Lei, Y Liu, Y Ye, J Li, K Sun - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
Fluoro-containing heterocycles are widely applied in agricultural, medicinal, imaging,
materials science and other fields due to their unique physical and chemical properties …
materials science and other fields due to their unique physical and chemical properties …
Reactivities of electrophilic N–F fluorinating reagents
N Rozatian, DRW Hodgson - Chemical Communications, 2021 - pubs.rsc.org
Electrophilic fluorination represents one of the most direct and useful methods available for
the selective introduction of fluorine into organic compounds. Electrophilic fluorinating …
the selective introduction of fluorine into organic compounds. Electrophilic fluorinating …