Fluorination methods in drug discovery

DE Yerien, S Bonesi, A Postigo - Organic & Biomolecular Chemistry, 2016 - pubs.rsc.org
Fluorination reactions of medicinal and biologically-active compounds will be discussed.
Late stage fluorination strategies of medicinal targets have recently attracted considerable …

Chlorinated solvents: their advantages, disadvantages, and alternatives in organic and medicinal chemistry

A Jordan, P Stoy, HF Sneddon - Chemical Reviews, 2020 - ACS Publications
Chlorinated Solvents: Their Advantages, Disadvantages, and Alternatives in Organic and
Medicinal Chemistry | Chemical Reviews ACS ACS Publications C&EN CAS Find my …

Fluorochemicals from fluorspar via a phosphate-enabled mechanochemical process that bypasses HF

C Patel, E André-Joyaux, JA Leitch… - Science, 2023 - science.org
All fluorochemicals—including elemental fluorine and nucleophilic, electrophilic, and radical
fluorinating reagents—are prepared from hydrogen fluoride (HF). This highly toxic and …

Where does the fluorine come from? A review on the challenges associated with the synthesis of organofluorine compounds

S Caron - Organic Process Research & Development, 2020 - ACS Publications
Fluorinated organic molecules are increasingly being prepared for a variety of applications,
including pharmaceutical products. However, the supply chain to access the necessary raw …

Application of metal oxide semiconductors in light-driven organic transformations

P Riente, T Noël - Catalysis Science & Technology, 2019 - pubs.rsc.org
The search for greener alternatives to perform organic reactions has become the order of the
day in the chemistry community. In this regard, the use of heterogeneous photocatalysts has …

Repurposing of F-gases: challenges and opportunities in fluorine chemistry

DJ Sheldon, MR Crimmin - Chemical Society Reviews, 2022 - pubs.rsc.org
Fluorinated gases (F-gases) are routinely employed as refrigerants, blowing agents, and
electrical insulators. These volatile compounds are potent greenhouse gases and …

Fluorine in the environment, a review of its sources and geochemistry

R Fuge - Applied Geochemistry, 2019 - Elsevier
While F is an essential constituent of some rock-forming minerals such as fluorite and
apatite, its major occurrence in the lithosphere is within hydroxysilicate minerals where F …

Electrooxidative dearomatization of biaryls: synthesis of tri-and difluoromethylated spiro [5.5] trienones

Y Zhang, C Ma, J Struwe, J Feng, G Zhu… - Chemical …, 2021 - pubs.rsc.org
Radical spirocyclization via dearomatization has emerged as an attractive strategy for the
rapid synthesis of structurally diverse spiro molecules. We report the use of electrochemistry …

Fluorination and fluoroalkylation of alkenes/alkynes to construct fluoro-containing heterocycles

X Wang, J Lei, Y Liu, Y Ye, J Li, K Sun - Organic Chemistry Frontiers, 2021 - pubs.rsc.org
Fluoro-containing heterocycles are widely applied in agricultural, medicinal, imaging,
materials science and other fields due to their unique physical and chemical properties …

Reactivities of electrophilic N–F fluorinating reagents

N Rozatian, DRW Hodgson - Chemical Communications, 2021 - pubs.rsc.org
Electrophilic fluorination represents one of the most direct and useful methods available for
the selective introduction of fluorine into organic compounds. Electrophilic fluorinating …