Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

L-type calcium channels couple membrane depolarization in neurons to numerous
processes including gene expression, synaptic efficacy, and cell survival. To establish the …

The molecular mechanisms controlling the termination of cortical interneuron migration are
unknown. Here, we demonstrate that, prior to synaptogenesis, migrating interneurons …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

Excessive body iron or iron overload occurs under conditions such as primary (hereditary)
hemochromatosis and secondary iron overload (hemosiderosis), which are reaching …

N-type calcium channels are critical for pain transduction. Inhibitors of these channels are
powerful analgesics, but clinical use of current N-type blockers remains limited by …

The L-type calcium channels (LTCCs) Ca v 1.2 and Ca v 1.3, encoded by the CACNA1C
and CACNA1D genes, respectively, are important regulators of calcium influx into cells and …

The neuronal L-type calcium channels (LTCCs) Cav1. 2α1 and Cav1. 3α1 are functionally
distinct. Cav1. 3α1 activates at lower voltages and inactivates more slowly than Cav1. 2α1 …

The spontaneous activity of pacemaker cells in the sino-atrial node controls the heart rhythm
and rate under physiological conditions. Compared to working myocardial cells, pacemaker …

Despite the success of combined antiretroviral therapy, more than half of HIV-1-infected
patients in the USA show HIV-associated neurological and neuropsychiatric deficits. This is …