Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …

The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …

The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic
activity of asparagine synthetase (ASNS). While ASNS and asparagine have been …

Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease that may
progress to fibrosis and/or cirrhosis. Treatment options are currently limited. The first-line …

Summary LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation
using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse …

O-linked bN-acetyl-glucosaminylation (O-GlcNAcylation) is one of the most common post-
translational modifications of proteins, and is established by modifying the serine or …

Background & Aims Changes in phosphatidylcholine levels in the liver have been
associated with the development of metabolic dysfunction–associated steatotic liver …

The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote
apoptosis resistance in various tissues and disease contexts; however, its role in liver cell …

Gene expression during natural and induced reprogramming is controlled by pioneer
transcription factors that initiate transcription from closed chromatin. Nr5a2 is a key pioneer …

Background & Aims Aflatoxin exposure increases the risk for hepatocellular carcinoma
(HCC) in hepatitis B virus (HBV)-infected individuals, particularly males. We investigated sex …