Nuclear receptors linking metabolism, inflammation, and fibrosis in nonalcoholic fatty liver disease
Nonalcoholic fatty liver disease (NAFLD) and its progressive form nonalcoholic
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …
steatohepatitis (NASH) comprise a spectrum of chronic liver diseases in the global …
The role and mechanism of oxidative stress and nuclear receptors in the development of NAFLD
T Hong, Y Chen, X Li, Y Lu - Oxidative medicine and cellular …, 2021 - Wiley Online Library
The overproduction of reactive oxygen species (ROS) and consequent oxidative stress
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
contribute to the pathogenesis of acute and chronic liver diseases. It is now acknowledged …
Asparagine protects pericentral hepatocytes during acute liver injury
Y Sun, H Demagny, A Faure… - The Journal of …, 2023 - Am Soc Clin Investig
The nonessential amino acid asparagine can only be synthesized de novo by the enzymatic
activity of asparagine synthetase (ASNS). While ASNS and asparagine have been …
activity of asparagine synthetase (ASNS). While ASNS and asparagine have been …
Obeticholic acid for primary biliary cholangitis
A Floreani, D Gabbia, S De Martin - Biomedicines, 2022 - mdpi.com
Primary biliary cholangitis (PBC) is a rare autoimmune cholestatic liver disease that may
progress to fibrosis and/or cirrhosis. Treatment options are currently limited. The first-line …
progress to fibrosis and/or cirrhosis. Treatment options are currently limited. The first-line …
[HTML][HTML] NR5A2/LRH-1 regulates the PTGS2-PGE2-PTGER1 pathway contributing to pancreatic islet survival and function
EM Vázquez, N Cobo-Vuilleumier, RA Legido… - Iscience, 2022 - cell.com
Summary LRH-1/NR5A2 is implicated in islet morphogenesis postnatally, and its activation
using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse …
using the agonist BL001 protects islets against apoptosis, reverting hyperglycemia in mouse …
Emerging role of protein O-GlcNAcylation in liver metabolism: implications for diabetes and NAFLD
Z Xie, T Xie, J Liu, Q Zhang, X Xiao - International journal of molecular …, 2023 - mdpi.com
O-linked bN-acetyl-glucosaminylation (O-GlcNAcylation) is one of the most common post-
translational modifications of proteins, and is established by modifying the serine or …
translational modifications of proteins, and is established by modifying the serine or …
Oral Supplementation of Phosphatidylcholine Attenuates the Onset of a Diet-Induced Metabolic Dysfunction–Associated Steatohepatitis in Female C57BL/6J Mice
V Sánchez, A Baumann, A Brandt, MF Wodak… - Cellular and Molecular …, 2024 - Elsevier
Background & Aims Changes in phosphatidylcholine levels in the liver have been
associated with the development of metabolic dysfunction–associated steatotic liver …
associated with the development of metabolic dysfunction–associated steatotic liver …
[HTML][HTML] Liver receptor homolog-1 (NR5A2) orchestrates hepatic inflammation and TNF-induced cell death
R Lambrecht, ME Delgado, V Gloe, K Schuetz… - Cell Reports, 2023 - cell.com
The nuclear receptor liver receptor homolog-1 (LRH-1) has been shown to promote
apoptosis resistance in various tissues and disease contexts; however, its role in liver cell …
apoptosis resistance in various tissues and disease contexts; however, its role in liver cell …
Nucleosome-bound NR5A2 structure reveals pioneer factor mechanism by DNA minor groove anchor competition
W Kobayashi, AH Sappler, D Bollschweiler… - Nature Structural & …, 2024 - nature.com
Gene expression during natural and induced reprogramming is controlled by pioneer
transcription factors that initiate transcription from closed chromatin. Nr5a2 is a key pioneer …
transcription factors that initiate transcription from closed chromatin. Nr5a2 is a key pioneer …
[HTML][HTML] Sex differences in genomic features of hepatitis B–associated hepatocellular carcinoma with distinct antitumor immunity
C Xu, S Cheng, K Chen, Q Song, C Liu, C Fan… - Cellular and Molecular …, 2023 - Elsevier
Background & Aims Aflatoxin exposure increases the risk for hepatocellular carcinoma
(HCC) in hepatitis B virus (HBV)-infected individuals, particularly males. We investigated sex …
(HCC) in hepatitis B virus (HBV)-infected individuals, particularly males. We investigated sex …