[HTML][HTML] Phenolic acids: Natural versatile molecules with promising therapeutic applications

N Kumar, N Goel - Biotechnology reports, 2019 - Elsevier
Plant phenolics are considered to be a vital human dietary component and exhibit a
tremendous antioxidant activity as well as other health benefits. Epidemiology evidence …

Antioxidants maintain cellular redox homeostasis by elimination of reactive oxygen species

L He, T He, S Farrar, L Ji, T Liu, X Ma - Cellular Physiology and …, 2017 - karger.com
Reactive oxygen species (ROS) are produced by living cells as normal cellular metabolic
byproduct. Under excessive stress conditions, cells will produce numerous ROS, and the …

Natural products for the treatment of type 2 diabetes mellitus: Pharmacology and mechanisms

L Xu, Y Li, Y Dai, J Peng - Pharmacological research, 2018 - Elsevier
Epidemiological studies have implied that diabetes mellitus (DM) will become an epidemic
accompany with metabolic and endocrine disorders worldwide. Most of DM patients are …

[HTML][HTML] Targeting PI3K/AKT signaling pathway in obesity

MS Savova, LV Mihaylova, D Tews, M Wabitsch… - Biomedicine & …, 2023 - Elsevier
Obesity is a disorder with an increasing prevalence, which impairs the life quality of patients
and intensifies societal health care costs. The development of safe and innovative …

[HTML][HTML] Pharmacological effects of gallic acid in health and diseases: A mechanistic review

N Kahkeshani, F Farzaei, M Fotouhi… - Iranian journal of …, 2019 - ncbi.nlm.nih.gov
Objective (s): Gallic acid is a natural phenolic compound found in several fruits and
medicinal plants. It is reported to have several health-promoting effects. This review aims to …

[HTML][HTML] Inflammation and oxidative stress in an obese state and the protective effects of gallic acid

PV Dludla, BB Nkambule, B Jack, Z Mkandla, T Mutize… - Nutrients, 2018 - mdpi.com
Metabolic complications in an obese state can be aggravated by an abnormal inflammatory
response and enhanced production of reactive oxygen species. Pro-inflammatory response …

Moroccan antidiabetic medicinal plants: Ethnobotanical studies, phytochemical bioactive compounds, preclinical investigations, toxicological validations and clinical …

A Bouyahya, N El Omari, N Elmenyiy… - Trends in Food Science …, 2021 - Elsevier
Background Moroccan flora is rich with medicinal plants that are widely used in traditional
medicine for the treatment of various diseases including diabetes. These plants possess …

Dietary polyphenols suppress chronic inflammation by modulation of multiple inflammation-associated cell signaling pathways

I Jantan, MA Haque, L Arshad, H Harikrishnan… - The Journal of nutritional …, 2021 - Elsevier
The high failure rate of the reductionist approach to discover effective and safe drugs to treat
chronic inflammatory diseases has led scientists to seek alternative ways. Recently …

[HTML][HTML] Insulin resistance, autophagy and apoptosis in patients with polycystic ovary syndrome: Association with PI3K signaling pathway

C Tong, Y Wu, L Zhang, Y Yu - Frontiers in Endocrinology, 2022 - frontiersin.org
Polycystic ovary syndrome (PCOS) is a disease in which endocrine metabolic abnormalities
coexist with reproductive system abnormalities, with the main clinical manifestations …

Antidiabetic effects of simple phenolic acids: A comprehensive review

R Vinayagam, M Jayachandran, B Xu - Phytotherapy research, 2016 - Wiley Online Library
Diabetes mellitus (DM) has become a major public health threat across the globe. Current
antidiabetic therapies are based on synthetic drugs that very often have side effects. It has …