Restless legs syndrome (RLS) is a common disorder. The population prevalence is 1.5% to
2.7% in a subgroup of patients having more severe RLS with symptoms occurring 2 or more …

Restless legs syndrome (RLS) is characterized by an uncomfortable urge to move the legs
while at rest, relief upon movement or getting up to walk, and worsened symptom severity at …

Adenosine plays a very significant role in modulating striatal glutamatergic and
dopaminergic neurotransmission. In the present essay we first review the extensive …

The restless legs syndrome is a common disorder that encompasses an idiopathic form of
genetic or unknown origin and symptomatic forms associated with many causes …

Restless legs syndrome (RLS) is a common sensorimotor disorder for which two main
pathological elements are fairly well accepted: Brain iron deficiency (BID) and an altered …

Abstract Purpose of Review To provide an overview of the molecular pathways and recent
genetic risk loci associated with restless legs syndrome/Willis-Ekbom disease (RLS/WED) …

Background Although several studies have shown the involvement of specific structures of
the central nervous system, the dopaminergic system, and iron metabolism in restless legs …

In this review, we aimed at identifying the studies that have employed repetitive transcranial
magnetic stimulation (rTMS) in patients with sleep disorders. Low-frequency (LF) rTMS …

Restless legs syndrome (RLS) is a sensorimotor neurological disorder characterised by an
urge to move the limbs with a circadian pattern (occurring in the evening/at night), more …

The functional and pharmacological significance of the dopamine D4 receptor (D4R) has
remained the least well understood of all the dopamine receptor subtypes. Even more …