Attenuation of inflammatory bowel disease by oral administration of mucoadhesive polydopamine-coated yeast β-glucan via ROS scavenging and gut microbiota …

F Yang, Y Su, C Yan, T Chen, PCK Cheung - Journal of …, 2024 - Springer
Abstract Treatment for inflammatory bowel disease (IBD) is challenging since current anti-
inflammatory and immunosuppressive therapies do not address the underlying causes of …

Harnessing Immunomodulatory Polymers for Treatment of Autoimmunity, Allergy, and Transplant Rejection

AB Tu, G Krishna, KR Smith… - Annual Review of …, 2024 - annualreviews.org
Autoimmunity, allergy, and transplant rejection are a collection of chronic diseases that are
currently incurable, drastically decrease patient quality of life, and consume considerable …

A synbiotic of Anaerostipes caccae and lactulose prevents and treats food allergy in mice

LA Hesser, AA Puente, J Arnold, E Ionescu, A Mirmira… - Cell Host & Microbe, 2024 - cell.com
Depletion of beneficial microbes by modern lifestyle factors correlates with the rising
prevalence of food allergies. Re-introduction of allergy-protective bacteria may be an …

Engineering nanoparticle therapeutics for food allergy

LM Rad, G Arellano, JR Podojil, JJ O'Konek… - Journal of Allergy and …, 2023 - Elsevier
Food allergy is a growing public health issue among children and adults that can lead to life-
threatening anaphylaxis following allergen exposure. The criterion standard for disease …

Novel strategies for modulating the gut microbiome for cancer therapy

YS Cho, K Han, J Xu, JJ Moon - Advanced Drug Delivery Reviews, 2024 - Elsevier
Recent advancements in genomics, transcriptomics, and metabolomics have significantly
advanced our understanding of the human gut microbiome and its impact on the efficacy …

Alleviating Pyroptosis of Intestinal Epithelial Cells to Restore Mucosal Integrity in Ulcerative Colitis by Targeting Delivery of 4-Octyl-Itaconate

W Li, D Chen, Y Zhu, Q Ye, Y Hua, P Jiang, Y Xiang… - ACS Nano, 2024 - ACS Publications
Current therapies primarily targeting inflammation often fail to address the root relationship
between intestinal mucosal integrity and the resulting dysregulated cell death and ensuing …

Lonicera caerulea Pomace Alleviates DSS-Induced Colitis via Intestinal Barrier Improvement and Gut Microbiota Modulation

B Zhang, X Huang, L Niu, X Chen, B Hu, X Tang - Foods, 2023 - mdpi.com
The objective of this investigation was to appraise the mitigative effects of Lonicera caerulea
pomace (LCP)-supplemented diets on Dextran Sulfate Sodium (DSS)-induced colitis, and to …

Injectable butyrate-prodrug micelles induce long-acting immune modulation and prevent autoimmune arthritis in mice

S Cao, E Budina, R Wang, M Sabados… - Journal of Controlled …, 2024 - Elsevier
Short chain fatty acid (SCFAs), such as butyrate, have shown promising therapeutic potential
due to their immunomodulatory effects, particularly in maintaining immune homeostasis …

Integrated metabolomics and transcriptomics revealed the anti-constipation mechanisms of xylooligosaccharides from corn cobs

H Song, R Guo, X Sun, Y Kou, X Ma, Y Chen, L Song… - Food & Function, 2024 - pubs.rsc.org
Xylooligosaccharides (XOSs) have recently garnered interest for their potential as an anti-
constipation agent. In this study, we investigated the effects of XOSs derived from corn cobs …

Glycosylation-modified antigens as a tolerance-inducing vaccine platform prevent anaphylaxis in a pre-clinical model of food allergy

S Cao, CD Maulloo, MM Raczy, M Sabados… - Cell Reports …, 2024 - cell.com
The only FDA-approved oral immunotherapy for a food allergy provides protection against
accidental exposure to peanuts. However, this therapy often causes discomfort or side …