Extracellular targets to reduce excessive scarring in response to tissue injury
J Fertala, ML Wang, M Rivlin, PK Beredjiklian… - Biomolecules, 2023 - mdpi.com
Excessive scar formation is a hallmark of localized and systemic fibrotic disorders. Despite
extensive studies to define valid anti-fibrotic targets and develop effective therapeutics …
extensive studies to define valid anti-fibrotic targets and develop effective therapeutics …
Normotensive placental extracellular vesicles provide long-term protection against hypertension and cardiovascular disease
Background Women with normotensive pregnancy are at a reduced risk of developing
cardiovascular disease postpartum compared with those who experience hypertensive …
cardiovascular disease postpartum compared with those who experience hypertensive …
Therapeutic strategies to overcome fibrotic barriers to nanomedicine in the pancreatic tumor microenvironment
Simple Summary Pancreatic cancer is difficult to treat. Novel treatment strategies are
urgently needed to improve the survival rate, which is approximately 10% five years after …
urgently needed to improve the survival rate, which is approximately 10% five years after …
Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis
Background Cardiac fibrosis is one of the top killers among fibrotic diseases and continues
to be a global unaddressed health problem. The lack of effective treatment combined with …
to be a global unaddressed health problem. The lack of effective treatment combined with …
[HTML][HTML] Tackling the effects of extracellular vesicles in fibrosis
M Martín-Taboada, P Corrales… - European Journal of …, 2022 - Elsevier
Fibrosis is a physiological process of tissue repair that turns into pathological when
becomes chronic, damaging the functional structure of the tissue. In this review we outline …
becomes chronic, damaging the functional structure of the tissue. In this review we outline …
Mare stromal endometrial cells differentially modulate inflammation depending on oestrus cycle status: an in vitro study
YS Wong, AC Mançanares, FI Navarrete… - Frontiers in Veterinary …, 2023 - frontiersin.org
The modulation of inflammation is pivotal for uterine homeostasis. Here we evaluated the
effect of the oestrus cycle on the expression of pro-inflammatory and anti-inflammatory …
effect of the oestrus cycle on the expression of pro-inflammatory and anti-inflammatory …
Mechanisms of doxorubicin-induced cardiac inflammation and fibrosis; therapeutic targets and approaches
L Song, Q Qiu, F Ju, C Zheng - Archives of Biochemistry and Biophysics, 2024 - Elsevier
Doxorubicin plays a pivotal role in the treatment of various malignancies. Despite its efficacy,
the cardiotoxicity associated with doxorubicin limits its clinical utility. The cardiotoxic nature …
the cardiotoxicity associated with doxorubicin limits its clinical utility. The cardiotoxic nature …
Schistosome egg antigen stimulates the secretion of miR-33-carrying extracellular vesicles from macrophages to promote hepatic stellate cell activation and liver …
X Qi, Y Pu, F Chen, L Dong, Y Ma, J Wang… - PLOS Neglected …, 2023 - journals.plos.org
Schistosomiasis is a serious and neglected disease with a high prevalence in tropical and
subtropical countries. The primary pathology of hepatic schistosomiasis caused by …
subtropical countries. The primary pathology of hepatic schistosomiasis caused by …
Hypoxia-preconditioned WJ-MSC spheroid-derived exosomes delivering miR-210 for renal cell restoration in hypoxia-reoxygenation injury
R Toghiani, V Azimian Zavareh, H Najafi… - Stem Cell Research & …, 2024 - Springer
Background Recent advancements in mesenchymal stem cell (MSC) technology have
paved the way for innovative treatment options for various diseases. These stem cells play a …
paved the way for innovative treatment options for various diseases. These stem cells play a …
[HTML][HTML] Therapeutic application of extracellular vesicles for various kidney diseases: a brief review
SA Lee, TH Yoo - BMB reports, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) released from different types of kidney cells under physiologic
conditions contribute to homeostasis maintenance, immune-modulation, and cell-to-cell …
conditions contribute to homeostasis maintenance, immune-modulation, and cell-to-cell …