Extracellular targets to reduce excessive scarring in response to tissue injury

J Fertala, ML Wang, M Rivlin, PK Beredjiklian… - Biomolecules, 2023 - mdpi.com
Excessive scar formation is a hallmark of localized and systemic fibrotic disorders. Despite
extensive studies to define valid anti-fibrotic targets and develop effective therapeutics …

Normotensive placental extracellular vesicles provide long-term protection against hypertension and cardiovascular disease

Y Feng, S Lau, Q Chen, C Oyston, K Groom… - American Journal of …, 2024 - Elsevier
Background Women with normotensive pregnancy are at a reduced risk of developing
cardiovascular disease postpartum compared with those who experience hypertensive …

Therapeutic strategies to overcome fibrotic barriers to nanomedicine in the pancreatic tumor microenvironment

HY Tanaka, T Nakazawa, A Enomoto, A Masamune… - Cancers, 2023 - mdpi.com
Simple Summary Pancreatic cancer is difficult to treat. Novel treatment strategies are
urgently needed to improve the survival rate, which is approximately 10% five years after …

Hypoxia enhances anti-fibrotic properties of extracellular vesicles derived from hiPSCs via the miR302b-3p/TGFβ/SMAD2 axis

M Paw, AA Kusiak, K Nit, JJ Litewka, M Piejko, D Wnuk… - BMC medicine, 2023 - Springer
Background Cardiac fibrosis is one of the top killers among fibrotic diseases and continues
to be a global unaddressed health problem. The lack of effective treatment combined with …

[HTML][HTML] Tackling the effects of extracellular vesicles in fibrosis

M Martín-Taboada, P Corrales… - European Journal of …, 2022 - Elsevier
Fibrosis is a physiological process of tissue repair that turns into pathological when
becomes chronic, damaging the functional structure of the tissue. In this review we outline …

Mare stromal endometrial cells differentially modulate inflammation depending on oestrus cycle status: an in vitro study

YS Wong, AC Mançanares, FI Navarrete… - Frontiers in Veterinary …, 2023 - frontiersin.org
The modulation of inflammation is pivotal for uterine homeostasis. Here we evaluated the
effect of the oestrus cycle on the expression of pro-inflammatory and anti-inflammatory …

Mechanisms of doxorubicin-induced cardiac inflammation and fibrosis; therapeutic targets and approaches

L Song, Q Qiu, F Ju, C Zheng - Archives of Biochemistry and Biophysics, 2024 - Elsevier
Doxorubicin plays a pivotal role in the treatment of various malignancies. Despite its efficacy,
the cardiotoxicity associated with doxorubicin limits its clinical utility. The cardiotoxic nature …

Schistosome egg antigen stimulates the secretion of miR-33-carrying extracellular vesicles from macrophages to promote hepatic stellate cell activation and liver …

X Qi, Y Pu, F Chen, L Dong, Y Ma, J Wang… - PLOS Neglected …, 2023 - journals.plos.org
Schistosomiasis is a serious and neglected disease with a high prevalence in tropical and
subtropical countries. The primary pathology of hepatic schistosomiasis caused by …

Hypoxia-preconditioned WJ-MSC spheroid-derived exosomes delivering miR-210 for renal cell restoration in hypoxia-reoxygenation injury

R Toghiani, V Azimian Zavareh, H Najafi… - Stem Cell Research & …, 2024 - Springer
Background Recent advancements in mesenchymal stem cell (MSC) technology have
paved the way for innovative treatment options for various diseases. These stem cells play a …

[HTML][HTML] Therapeutic application of extracellular vesicles for various kidney diseases: a brief review

SA Lee, TH Yoo - BMB reports, 2022 - ncbi.nlm.nih.gov
Extracellular vesicles (EVs) released from different types of kidney cells under physiologic
conditions contribute to homeostasis maintenance, immune-modulation, and cell-to-cell …