Background Brain cancer is a destructive and life-threatening disease that imposes
immense negative effects on patients' lives. Therefore, the detection of brain tumors at an …

Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …

Neuronal development in the human cerebral cortex is considerably prolonged compared
with that of other mammals. We explored whether mitochondria influence the species …

Background Increasing evidence supported the possible neuro-invasion potential of SARS-
CoV-2. However, no studies were conducted to explore the existence of the micro-structural …

Proliferating cells exhibit a metabolic phenotype known as" aerobic glycolysis," which is
characterized by an elevated rate of glucose fermentation to lactate irrespective of oxygen …

The contribution of inflammation to the chronic joint disease osteoarthritis (OA) is unclear,
and this lack of clarity is detrimental to efforts to identify therapeutic targets. Here we show …

Elevated glycolysis remains a universal and primary character of cancer metabolism, which
deeply depends on dysregulated metabolic enzymes. Lactate dehydrogenase A (LDHA) …

Environmental factors are the largest contributors to cardiovascular disease. Here we show
that cardiac organoids that incorporate an oxygen-diffusion gradient and that are stimulated …

Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

In recent years there has been a growing interest among cancer biologists in cancer
metabolism. This Review summarizes past and recent advances in our understanding of the …