Chemoresistance, whether intrinsic or acquired, is a major obstacle in the treatment of
cancer. The resistance of cancer cells to chemotherapeutic drugs can result from various …

The interplay between Ca 2+ and reactive oxygen species (ROS) signaling pathways is well
established, with reciprocal regulation occurring at a number of subcellular locations. Many …

Neutrophils play a critical role in cancer, with both protumor and antitumor neutrophil
subpopulations reported. The antitumor neutrophil subpopulation has the capacity to kill …

Abstract The Forkhead box O (FoxO) family has recently been highlighted as an important
transcriptional regulator of crucial proteins associated with the many diverse functions of …

Long noncoding RNAs (lncRNAs) are emerging as important regulators of tumorigenesis
and are frequently dysregulated in cancers. Here, we identify a critical lncRNA TRPM2-AS …

The TRP ion channel TRPM2 has an essential function in cell survival and protects the
viability of a number of cell types after oxidative stress. It is highly expressed in many …

Hypoxia (HYPX) induced-overload Ca2+ entry results in increase of mitochondrial oxidative
stress, inflammation and apoptosis in several neurons. Ca2+ permeable TRPM2 channel …

A lack of effective treatment is one of the main factors contributing to gastric cancer–related
death. Discovering effective targets and understanding their underlying anti-cancer …

The transient receptor potential melastatin subfamily member 2 (TRPM2), a thermo and
reactive oxygen species (ROS) sensitive Ca2+-permeable cation channel has a vital role in …

Tissue injury can initiate bidirectional signaling between neurons, glia, and immune cells
that creates and amplifies pain. While the ability for neurotransmitters, neuropeptides, and …