Emerging role of YAP/TAZ in vascular mechanotransduction and disease
O Ritsvall, S Albinsson - Microcirculation, 2024 - Wiley Online Library
Cells have an incredible ability to physically interact with neighboring cells and their
environment. They can detect and respond to mechanical forces by converting mechanical …
environment. They can detect and respond to mechanical forces by converting mechanical …
Cell-type specific regulator RBPMS switches alternative splicing via higher-order oligomerization and heterotypic interactions with other splicing regulators
Y Yang, GC Lee, E Nakagaki-Silva… - Nucleic Acids …, 2023 - academic.oup.com
Alternative pre-mRNA splicing decisions are regulated by RNA binding proteins (RBPs) that
can activate or repress regulated splice sites. Repressive RBPs typically harness multivalent …
can activate or repress regulated splice sites. Repressive RBPs typically harness multivalent …
[HTML][HTML] Suppression of smooth muscle cell inflammation by myocardin-related transcription factors involves inactivation of TANK-binding kinase 1
Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and
MRTF-B/MRTFB) suppress production of pro-inflammatory cytokines and chemokines in …
MRTF-B/MRTFB) suppress production of pro-inflammatory cytokines and chemokines in …
Meta-Analysis of Genome-Wide Association Studies Reveals Genetic Mechanisms of Supraventricular Arrhythmias
BACKGROUND: Substantial data support a heritable basis for supraventricular
tachycardias, but the genetic determinants and molecular mechanisms of these arrhythmias …
tachycardias, but the genetic determinants and molecular mechanisms of these arrhythmias …
Itga8-Cre-mediated deletion of YAP and TAZ impairs bladder contractility with minimal inflammation and chondrogenic differentiation
L Liu, M Arévalo-Martínez, C Rippe… - … of Physiology-Cell …, 2023 - journals.physiology.org
A role of Yes1-associated transcriptional regulator (YAP) and WW domain-containing
transcription regulator 1 (TAZ) in vascular and gastrointestinal contractility due to control of …
transcription regulator 1 (TAZ) in vascular and gastrointestinal contractility due to control of …
Phosphorylation of the smooth muscle master splicing regulator RBPMS regulates its splicing activity
MD Barnhart, Y Yang, EE Nakagaki-Silva… - Nucleic Acids …, 2022 - academic.oup.com
We previously identified RBPMS as a master regulator of alternative splicing in differentiated
smooth muscle cells (SMCs). RBPMS is transcriptionally downregulated during SMC …
smooth muscle cells (SMCs). RBPMS is transcriptionally downregulated during SMC …
RBPMS promotes contractile smooth muscle splicing and alters phenotypic behaviour of human embryonic stem cell derived vascular smooth muscle cells
Abstract Differentiated Vascular Smooth Muscle Cells (VSMCs) express a unique network of
splice isoforms (smooth muscle specific alternative splicing-SM-AS) in functionally critical …
splice isoforms (smooth muscle specific alternative splicing-SM-AS) in functionally critical …
Mechanism of an alternative splicing switch mediated by cell-specific and general splicing regulators
Y Yang, GC Lee, E Nakagaki-Silva, Y Huang… - bioRxiv, 2023 - biorxiv.org
Alternative pre-mRNA splicing is regulated by RNA binding proteins (RBPs) that activate or
repress regulated splice sites. Repressive RBPs bind stably to target RNAs via multivalent …
repress regulated splice sites. Repressive RBPs bind stably to target RNAs via multivalent …