Protein palmitoylation and depalmitoylation alter protein function. This post-translational
modification is critical for synaptic transmission and plasticity. Mutation of the …

N-methyl-d-aspartate receptors (NMDARs) play a critical role in synaptic signaling, and
alterations in the synaptic/extrasynaptic NMDAR balance affect neuronal survival. Studies …

Postsynaptic density 95 (PSD-95), the major scaffold at excitatory synapses, is critical for
synapse maturation and learning. In rodents, eye opening, the onset of pattern vision …

S-acylation, also known as S-palmitoylation or palmitoylation, is a reversible post-
translational lipid modification in which long chain fatty acid, usually the 16-carbon …

Recent advances in our understanding of the intracellular trafficking, membrane
microenvironment, and subcellular sites of signaling of Ras have been driven by …

Palmitoylation, the dynamic post-translational addition of the lipid, palmitate, to proteins by
Asp-His-His-Cys-containing palmitoyl acyltransferase (PAT) enzymes, modulates protein …

Type 1 diabetes (T1D) is a complex disease characterized by the loss of insulin-secreting β-
cells. Although the disease has a strong genetic component, and several loci are known to …

Palmitoylation, more correctly known as S-acylation, aids in the regulation of cellular
functions including stress response, disease resistance, hormone signalling, cell …

Polyglutamine expansions of huntingtin protein are responsible for the Huntington
neurological disorder. HIP14 protein has been shown to interact with huntingtin. HIP14 and …

Protein palmitoylation is a reversible lipid modification that plays important roles for many
proteins involved in signal transduction, but relatively little is known about the regulation of …