S-Palmitoylation is a reversible post-translational modification that results in the addition of a
C16-carbon saturated fatty acyl chain to cytoplasmic cysteine residues. This modification is …

Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty
acid palmitate to cysteine residues, which influences trafficking, localization, and protein …

Protein palmitoylation is a post‐translational modification that affects a great number of
proteins. In most cases, the enzymes responsible for this modification have not been …

A large number of mammalian Mg2+ transporters have been hypothesized on the basis of
physiological data, but few have been investigated at the molecular level. The recent …

Loss-of-function mutations in the depalmitoylating enzyme palmitoyl protein thioesterase 1
(PPT1) cause neuronal ceroid lipofuscinosis (NCL), a devastating neurodegenerative …

Pharmacologic approaches to studying palmitoylation are limited by the lack of specific
inhibitors. Recently, screens have revealed five chemical classes of small molecules that …

Protein S-palmitoylation refers to a post-translational modification (PTM) wherein palmitic
acid, a 16-carbon long saturated fatty acid gets covalently attached to Cys sidechain of a …

H-ras is anchored to the plasma membrane by two palmitoylated cysteine residues, Cys181
and Cys184, operating in concert with a C-terminal S-farnesyl cysteine carboxymethylester …

S‐acylation (palmitoylation) is a poorly understood post‐translational modification of
proteins involving the addition of acyl lipids to cysteine residues. S‐acylation promotes the …

Huntington's disease (HD) is a fatal and pure genetic disease with a progressive loss of
medium spiny neurons (MSN). HD is caused by expanded polyglutamine repeats in the …