Post-translational modification by covalent attachment of lipid groups helps proteins to
associate with membranes, both intra-and extracellularly. The enzymology of protein S …

Protein palmitoylation, the thioester linkage of fatty acyl moieties (typically, saturated 16C
palmitate) to cysteine, is a lipid modification that serves both to tether proteins to membranes …

Excitotoxicity plays a key role in the selective vulnerability of striatal neurons in Huntington
disease (HD). Decreased glutamate uptake by glial cells could account for the excess …

Scaffold proteins are abundant and essential components of the postsynaptic density (PSD).
They play a major role in many synaptic functions including the trafficking, anchoring, and …

The efficacy and success of many cellular processes is dependent on a tight orchestration of
proteins trafficking to and from their site (s) of action in a time-controlled fashion. Recently, a …

Protein palmitoylation, by modulating the dynamic interaction between protein and cellular
membrane, is involved in a wide range of biological processes, including protein trafficking …

Numerous proteins undergo modification by palmitic acid (S-acylation) for their biological
functions including signal transduction, vesicular transport and maintenance of cellular …

The postsynaptic density (PSD) consists of a lattice-like array of interacting proteins that
organizes and stabilizes synaptic receptors, ion channels, structural proteins, and signaling …

Syt VII is a Ca2+ sensor that regulates lysosome exocytosis and plasma membrane repair.
Because it lacks motifs that mediate lysosomal targeting, it is unclear how Syt VII traffics to …

The majority of neuronal proteins involved in cellular signaling undergo different
posttranslational modifications significantly affecting their functions. One of these …