[HTML][HTML] Structural basis for substrate recognition by the ankyrin repeat domain of human DHHC17 palmitoyltransferase
DHHC enzymes catalyze palmitoylation, a major post-translational modification that
regulates a number of key cellular processes. There are up to 24 DHHCs in mammals and …
regulates a number of key cellular processes. There are up to 24 DHHCs in mammals and …
Huntingtin-interacting protein 14, a palmitoyl transferase required for exocytosis and targeting of CSP to synaptic vesicles
T Ohyama, P Verstreken, CV Ly, T Rosenmund… - The Journal of cell …, 2007 - rupress.org
Posttranslational modification through palmitoylation regulates protein localization and
function. In this study, we identify a role for the Drosophila melanogaster palmitoyl …
function. In this study, we identify a role for the Drosophila melanogaster palmitoyl …
Accessory proteins of the zDHHC family of S-acylation enzymes
C Salaun, C Locatelli, F Zmuda… - Journal of Cell …, 2020 - journals.biologists.com
Almost two decades have passed since seminal work in Saccharomyces cerevisiae
identified zinc finger DHHC domain-containing (zDHHC) enzymes as S-acyltransferases …
identified zinc finger DHHC domain-containing (zDHHC) enzymes as S-acyltransferases …
Discovery of protein-palmitoylating enzymes
R Tsutsumi, Y Fukata, M Fukata - Pflügers Archiv-European Journal of …, 2008 - Springer
Posttranslational modification provides proteins with additional function and regulatory
control beyond genomic information, allowing cells to maintain homeostasis and respond to …
control beyond genomic information, allowing cells to maintain homeostasis and respond to …
[HTML][HTML] The lipid habitats of neurotransmitter receptors in brain
Neurotransmitter receptors, the macromolecules specialized in decoding the chemical
signals encrypted in the chemical signaling mechanism in the nervous system, occur either …
signals encrypted in the chemical signaling mechanism in the nervous system, occur either …
[HTML][HTML] Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease
Protein palmitoylation, a reversible lipid modification of proteins, is widely used in the
nervous system, with dysregulated palmitoylation being implicated in a variety of …
nervous system, with dysregulated palmitoylation being implicated in a variety of …
Trafficking of the microdomain scaffolding protein reggie-1/flotillin-2
MF Langhorst, A Reuter, FA Jaeger, FM Wippich… - European journal of cell …, 2008 - Elsevier
The reggie/flotillin proteins oligomerize and associate into clusters which form scaffolds for
membrane microdomains. Besides their localization at the plasma membrane, the …
membrane microdomains. Besides their localization at the plasma membrane, the …
[HTML][HTML] Palmitoylation targets AKAP79 protein to lipid rafts and promotes its regulation of calcium-sensitive adenylyl cyclase type 8
I Delint-Ramirez, D Willoughby, GVR Hammond… - Journal of biological …, 2011 - ASBMB
PKA anchoring proteins (AKAPs) optimize the efficiency of cAMP signaling by clustering
interacting partners. Recently, AKAP79 has been reported to directly bind to adenylyl …
interacting partners. Recently, AKAP79 has been reported to directly bind to adenylyl …
Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14
K Huang, SS Sanders, R Kang… - Human Molecular …, 2011 - academic.oup.com
Huntington disease (HD) is caused by polyglutamine expansion in the huntingtin (HTT)
protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing …
protein. Huntingtin-interacting protein 14 (HIP14), one of 23 DHHC domain-containing …
[HTML][HTML] DHHC5 interacts with PDZ domain 3 of post-synaptic density-95 (PSD-95) protein and plays a role in learning and memory
A family of integral membrane proteins containing a signature DHHC motif has been shown
to display protein S-acyltransferase activity, modifying cysteine residues in proteins with fatty …
to display protein S-acyltransferase activity, modifying cysteine residues in proteins with fatty …