Lysosomal acidification dysfunction has been implicated as a key driving factor in the
pathogenesis of neurodegenerative diseases, including Alzheimer's disease and …

Cathepsins encompass a family of lysosomal proteases that mediate protein degradation
and turnover. Although mainly localized in the endolysosomal compartment, cathepsins are …

ABSTRACT 2019 coronavirus disease (COVID-19) is a disease caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). In addition to respiratory illness, COVID …

Papain-like cysteine proteases are composed of 11 human cysteine cathepsins, originally
located in the lysosomes. They exhibit broad specificity and act as endopeptidases and/or …

Background Lysosomal dysfunction has been implicated in a number of neurodegenerative
diseases such as Parkinson's disease (PD). Various molecular, clinical and genetic studies …

Parkinson's disease (PD) is the second most common neurodegenerative disorder after
Alzheimer's disease, and its prevalence is increasing with age. A wealth of genetic evidence …

Background Neuroinflammation is involved in the pathophysiology of Alzheimer's disease
(AD), including immune-linked genetic variants and molecular pathways, microglia and …

Lysosomes are specialized organelles with an acidic pH that act as recycling hubs for
intracellular and extracellular components. They harbour numerous different hydrolytic …

Aging is a ubiquitous biological process that limits the maximal lifespan of most organisms.
Significant efforts by many groups have identified mechanisms that, when triggered by …

Fluoride is capable of inducing developmental neurotoxicity; regrettably, the mechanism is
obscure. We aimed to probe the role of lysosomal biogenesis disorder in developmental …