Rhabdomyosarcoma (RMS) is a common soft tissue sarcoma in children that resembles
developing skeletal muscle. Unlike normal muscle cells, RMS cells fail to differentiate …

Myogenesis is a highly regulated process that involves the conversion of progenitor cells
into multinucleated myofibers. Besides proteins and mi RNA s, long noncoding RNA s (lnc …

Rhabdomyosarcoma (RMS) is an aggressive pediatric malignancy of the muscle, that
includes Fusion Positive (FP)-RMS harboring PAX3/7-FOXO1 and Fusion Negative (FN) …

Duchenne muscular dystrophy (DMD) is a multisystemic disorder that affects 1: 5000 boys.
The severity of the phenotype varies dependent on the mutation site in the DMD gene and …

Characterizing the ontologies of genes directly regulated by a transcription factor (TF), can
help to elucidate the TF's biological role. Previously, we developed a widely used method …

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma of childhood, with
presumed skeletal muscle origins, because of its myogenic phenotype. RMS is composed of …

The transcriptional regulatory network that controls the determination and differentiation of
skeletal muscle cells in the embryo has at its core the four myogenic regulatory factors (MRF …

MyoD is a key regulator of skeletal myogenesis that directs contractile protein synthesis, but
whether this transcription factor also regulates skeletal muscle metabolism has not been …

While MEF2 transcription factors are well known to cooperate in orchestrating cell fate and
adaptive responses during development and adult life, additional studies over the last …

Following myonecrosis, muscle satellite cells proliferate, differentiate and fuse, creating new
myofibers. The Runx1 transcription factor is not expressed in naïve developing muscle or in …